A neat and rapid procedure is reported for the synthesis of a variety of (2-aroyl-5-hydroxy-1,3,5-triaryl-4-piperidyl)(aryl)methanone (3a-3g) by the condensation of 2-[(2-oxo-2-arylethyl)anilino]-1-aryl-1-ethanones 1 with different arylidene acetophenone 2 under microwave irradiation.

Dihydropyridines derivative have been synthesized by one‐pot multicomponent cyclocondensation reaction using PBI‐PPh3 catalyst. This catalyst is characterized by the solid state of 13C‐NMR, 15N‐NMR, and 31P‐NMR spectrum, FT‐IR, cyclic voltammetry, and XRD analysis. The selection of catalyst is quite interesting because of its affordability, toxic free nature and high stability. Functional groups of all dihydropyridines confirms by H1‐NMR and FTIR spectra. Synthesized compounds show exceptional yields of 96–99 %. Synthesized compounds has evaluated for their invitro antibacterial activity against B. subtilis, and P. vulgaris (ATCC 49565) and C. albicans (ATCC 90028). Synthesized dihydropyridines showed promising antibacterial and antifungal activities, in particularly, ethyl‐4‐(4‐methylphenyl)‐2,7,7‐trimethyl‐5‐oxo‐1,4,5,6,7,8‐hexadihydropyridine‐3‐carboxylate are exhibiting a higher inhibition zone of 66.7 % against bacteria. Our method may help to drug chemists for design more interesting, useful, and sustainable reactions in the near future.