A simple and very sensitive electrochemical sensor for the detection of uric acid (UA) has been developed based on polyaniline (PANI) merged into a silver-doped iron oxide (Ag-FeO) nanocomposite-modified glassy carbon electrode. The synthesized ternary composite material (Ag-FeO@PANI) was characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray, High-resolution transmission electron microscopy, X-ray diffraction, and thermo gravimetric analysis analyses. The nanocomposite-modified electrode shows an exceptional electrocatalytic activity and reversibility to the oxidation of UA in a 0.1 M phosphate buffer solution (pH 7.0) compared to those in PANI and Ag-FeO. The detection limit of UA is found to be 102 pM with a linear dynamic range of 0.001-0.900 μM. The fabricated UA sensor also exhibits good selectivity, reproducibility, and long-time stability. The limit of detection and linear range attained for the synthesized composite are much greater compared to those of any other composite materials reported in the literature. The proposed method has been successfully applied for the selective detection of UA in various real samples such as human serum and urine with good recoveries. This platform that assimilates such electrocatalytic ternary nanocomposite with high performance can be widely employed for fabricating diverse sensors.

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The novel N-CeO nanoparticles decorated on reduced graphene oxide (N-CeO@rGO) composite has been synthesized by sonochemical method. The characterization of as prepared nanocomposite was intensely performed by UV-Vis, FT-IR, EDX, FE-SEM, HR-TEM, XRD, and TGA analysis. The synthesized nanomaterial was further investigated for its selective and sensitive sensing of paracetamol (PM) based on a N-CeO@rGO modified glassy carbon electrode. A distinct and improved reversible redox peak of PM is obtained at N-CeO@rGO nanocomposite compared to the electrodes modified with N-CeO and rGO. It displays a very good performance with a wide linear range of 0.05-0.600 μM, a very low detection limit of 0.0098 μM (S/N = 3), a high sensitivity of 268 μA µM cm and short response time (<3 s). Also, the fabricated sensor shows a good sensibleness for the detection of PM in various tablet samples.

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