Background: To study the comparative outcome between resolved an unresolved ST segment in ST Segment Elevation Acute Myocardial Infarction (STEMI), after thrombolytic therapy. Method: A study was carried out on patients admitted with 1st episode of ST elevated myocardial infarction in MICU of a tertiary health care center of a teaching hospital. On admission detailed history was taken and a complete clinical examination was done. Thrombolysis was done using streptokinase, 2D ECHOs were performed before and after thrombolytic therapy. Result: Most of the study population in both the group (Unresolved STEMI and Successful thrombolysis), belonged to the age group of 41 to 50 years. Co-morbidities like hypertension were present in 83% of Unresolved STEMI and 53% of Resolved STEMI. Comorbidities like diabetes were present in 66.7% of Unresolved STEMI and 52.6% of Resolved STEMI. RWMA on 2D-Echo before thrombolysis was present in 58.3% of Unresolved STEMI and 47.4% of Resolved STEMI. RWMA on 2D-Echo after thrombolysis was present in 66.7% of Unresolved STEMI and 18.5% of Resolved STEMI. Conclusion: Symptom to needle time is an important predictor of whether thrombolysis will be successful or not in acute myocardial infarction patients. Hence it is important to educate the public about prompt recognition of symptoms and seeking medical help urgently. As the rate of unsuccessful thrombolysis is higher in patients with old age, diabetes, hypertension and dyslipidemia, such patients should be monitored and treated aggressively.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. HT and DM have been recognized to coexist with COPD. Several risk factors have been associated with HT and DM in people with COPD: Smoking, systemic inflammation, obesity and physical inactivity. Objective: To estimate Prevalence of diabetes and hypertension in Chronic Obstructive Pulmonary Diseases amongst study participants. Material and Method: The Cross-sectional study was conducted on 161 diagnosed COPD patients from August 2017 to December 2019 in Department of Respiratory Medicine Medical College and Tertiary Health Care Institute Nashik was included. Written informed consent was taken from all study participants and those who gave consent were enrolled in the present study. Result: Out of 161 COPD patients, prevalence of hypertension was 45.96% while prevalence of DM was 22.36%. The Highest prevalence of DM in Female (33.33%), HTN in Male (48%) and both DM and HTN in Female (8.33%), active smokers were mostly associated with DM and/or HTN. In stage IV (71), DM, HTN and both DM and HTN were recorded in maximum no. of cases, whereas in patients of Stage I - COPD least level were found. Increase association of DM and/or HTN increases with severity of obstruction. Conclusion: Prevalence of HTN was recorded more than DM. DM and HTN were found to be more prevalence in severe and very severe COPD patients. The COPD patients should be screened for DM and HTN at the time of diagnosis to prevent DM and/or HTN related complications in COPD patients.