New substituted thieno[3,2-c]pyridine derivatives 5 were synthesized by the reaction of 3-bromo-4-chlorothieno[3,2-c]pyridine 1 with cyclic amine 2, which further on Suzuki reaction with boronic acids 4 converted to corresponding 3-arylthieno[3,2-c]pyridine 5. Substituent R has predominant effect on fluorescence properties of thienopyridines. However, the electron donor amine at C has no effect on fluorescence properties of thienopyridines. Graphical Abstract New thieno[3,2-c]pyridine derivatives were synthesized from 3-bromo-4-chlorothieno[3,2-c]pyridine and cyclic amines, which by on Suzuki reaction with boronic acids converted to corresponding 3-arylthieno[3,2-c]pyridine. Substituent R3 has predominant effect on fluorescence properties of thienopyridines. However, the electron donor amine at C4 has no effect on fluorescence properties of thienopyridines.

Poly substituted 3-aminothiophenes were successfully synthesized in good yields by using a one-pot protocol via ketene S,S-acetal as an intermediate in basic medium (K 2 CO 3 /N,N-dimethylformamide) followed by Dieckmann condensation with ethyl bromoacetate. Further, chemistry of thiophenes was explored using active functional groups such as C 3 -NH 2 , C 4 -CN and C 5 -SCH 3 on the thiophene nucleus.Synthesis of ethyl 3-acetamido-4-cyano-5-(methylthio)thiophene-2-carboxylate derivatives and ethyl 3-amino-4-carbamoyl-5-(methylt hio)thiophene-2-carboxylate derivatives. S COOEt NH-R S H2N O S COOEt NC S NH-R S COOEt NC S NH2 O NH Ar O NH Ar Ar = C6H5, 4-MeOC6H4, 4-ClC6H4 R = H, Acetyl, chloroacetyl, pyrrolyl ARTICLE HISTORY

New intermediate 3‐methyl‐5‐oxopyrazol propanenitrile was synthesized by one pot three component reactions using ethyl cyanoacetate, hydrazine hydrate, and ethyl acetoacetate and was used for the synthesis of new oxazole and pyrazole derivatives. All reactions were carried out using eco‐friendly solvents and without catalyst.

Series of tetrahydrobenzo[b]thiophen-2-yl)-N, N-dimethylformamidine derivatives were synthesizedfrom 2-amino-4, 5, 6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile. The new derivatives were checked good antimicrobial activities against S. aureus, E. coli and C. albicans, and A. Niger microbes.