An inexpensive, powerful, and eco-friendly method for transition-metal-free oxidative C(sp 3 )À H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.

Biaryls are important compounds with widespread applications in many fields. Tetramethylammonium fluoride tetrahydrate was found to promote the biaryl coupling of aryl iodides bearing electron-withdrawing substituents with unactivated arenes. The reaction takes place at temperatures between 100 and 150°C and can be applied to a wide range of aromatic and heteroaromatic rings, affording the products in moderate to high yields. The reaction does not require strong bases or expensive additives that are employed in the existing methods and can be conducted in air and moisture without any precautions.

Herein, we describe the copper-catalyzed aerobic C(sp3)–H functionalization of 2-alkylbenzamides for the synthesis of benzolactones. This reaction proceeds via 1,5-hydrogen atom transfer of N-centered radicals directly generated by N–H bond...

A transition‐metal‐free oxidative C(sp3)−H bond lactonization was developed using sodium peroxydisulfate (Na2S2O8) as the sole oxidant. This is a straightforward, inexpensive, powerful, and eco‐friendly method for the synthesis of lactones. This process could be applied to various 2‐alkylbenzoic acids containing a primary, secondary, or tertiary carbon at the benzylic position. Furthermore, a variety of functional groups such as halogen, cyano, nitro, and hydroxy groups were tolerated under the reaction conditions. More information can be found in the Communication by Kanako Nozawa‐Kumada, Yoshinori Kondo et al. on page 1080 in Issue 7, 2019 (DOI: 10.1002/ajoc.201900167).