Introduction: Mind Sound Resonance Technique (MSRT) is a yogic relaxation technique, which creates a resonance of the “A,” “U,” “M,” “AUM,” and Mahämåtyuïjaya mantra chanting to provide a delicate massage sensation throughout the body. Adolescence is a developmental stage marked by changes in social, emotional, and cognitive functioning. Studies have demonstrated the benefits of yoga, pranayama, and meditation regarding health and mental issues in both adolescents and adults. Aim: To see the effect of the MSRT on selected psycho-emotional parameters in secondary school students. Materials and Methods: In this randomised controlled trial, data of total 63 adolescents (intervention group (n=32) and control group (n=31) were analysed, who were selected from two English medium schools in Udaipur, Tripura (northeast India). The intervention group was provided the MSRT for 30 minutes each day for 21 sessions, whereas the control group went through only the daily routine, in the month of April 2022. The data were collected using questionnaires, prior to and after the intervention. Independent sample test and paired sample t-test were done for ‘between groups’ and ‘within group’ comparison respectively for the variables i.e., emotion regulation, impulsivity, creative thinking, critical thinking, and interpersonal relationship. Mann-whitney test and Wilcoxon-signed rank test were done for ‘between groups’ and ‘within group’ comparison, respectively for the variables i.e., aggression and mindfulness. Results: The intervention group showed significant improvement in mindfulness (p<0.001), creative thinking (p<0.001), critical thinking (p<0.001), interpersonal relationship (p<0.001), emotion regulation (p=0.005) and a significant reduction in aggression (p<0.001) and impulsivity (p=0.001) compared to control group. Conclusion: Based on the result of the present study it is suggested that MSRT can help to improve the psycho-emotional well-being of adolescents.