Background: Many attempts have been described to stablish peripheral blood ratios as systemic immune biomarkers in lung cancer, unfortunately they are not still considered because of lack accuracy and sensibility. In this study, we explore and correlate clinical stages to median values of peripheral blood ratios as Neutrophil-to-lymphocyte ratio (NLR), Monocyte-to-lymphocyte ratio (MLR) and Platelets-tolymphocyte ratio (PLR) among patients with lung cancer. Method: Retrospectively, we review clinical and laboratory data from 193 patients with lung cancer treated at Oncosalud e AUNA from 2011 to 2014. The laboratory data (hemoglobin, leukocytes, neutrophil, lymphocyte and monocyte) were collected from blood routine test obtained from the first clinic visit. The median (range) and mean (± SD) of the ratios were determined according every clinical stage and compared using the U Mann Whitney test. Result: Median age was 67 years, and 63 (

dissection, with the latissimus dorsi and serratus anterior muscles were protected, no rib cut needed. Case 1: right lower lobe lobectomy was performed first, frozen pathological diagnosis: inflammatory lesion with pneumocyte dysplasia, locally with hemangioma-like lesion. Wedge resection was performed to remove the nodule at right middle lobe. Postoperative pathology: both tumors were sclerosing hemangioma of the lung (Aug 2012). Case 2: enucleation was performed, frozen pathological diagnosis: sclerosing hemangioma of the lung, malignancy should be excluded by later paraffin slides staining. Right upper lobe lobectomy with mediastinal lymph node dissection was performed. Postoperative pathology: sclerosing hemangioma of the lung, no lymph node metastasis (Nov 2012). Both patients recovered much better and more quickly than other patients who underwent TSPT in the same ward at that time. Regular follow-up: both are alive healthily in their 4th year postoperatively, no recurrence and metastasis. No adjuvant treatment was used. Conclusion: Multiple sclerosing pneumocytomas are rare. For sclerosing pneumocytoma, surgical resection is of first choice. Limited resection should be enough and reasonable for this kind of benign tumor, however, lobectomy becomes essential once the tumor size is too big, further, mediastinal lymph node dissection is to be performed when malignancy is suspected. miMRST, is minimally invasive thoracic surgery, with no need to use expensive thoracoscopic devices, is very suitable for lung surgery in developing countries.

This paper is studied the respiratory function as a result of the impact of air pollution in the environment of the sector of exploitation of heavy minerals such Pb, Zn, Au, Ag, Bi, Cd, PM in the mines of Trepça, Kosovo. Lung function parameters are determined by Body plethysmography. Airway resistance (Raw) was recorded and Intra-Thoracic Gas Volume (ITGV) was measured and specific resistance (SRaw) and airway specific conductance (SGaw) were calculated. The research was done in two groups, the control group and the experimental one. The control group consisted of 24 healthy people, while the experimental one is made up of 52 mining workers for the exploitation of minerals in the Trepçamine, Kosovo. The results obtained from this research indicate that the mean value of specific resistance (SRaw) is significantly higher in the experimental group (p<0.01), compared to the control group (p>0.1). Also, in this study it was confirmed that smoking favors the negative effects of air contamination in the mineral exploitation sector, the changes are significant (p<0.01). Respiratory system parameters of the control group and the experimental group were measured before and after bronchoprovocation with histamine-aerosol (1 mg/ml). The differences between these two groups after provocation were statistically significant (p<0.01). Respiratory changes from air pollution with noxae in mines where metals are mined, it takes a long time for changes in respiratory function to appear. Therefore, exposure of workers to these conditions poses a risk to their health, causing bronchial reactivity, bronchial asthma or, obstructive pulmonary syndrome.

Context: Kosovo is a region in the Western Balkans that is rich in minerals and coal, so pollution is a serious public health problem there. Workers in the heavy and precious metal smeltery in Zveqan, Kosovo, were studied with regard to the roles that vapor from the smelting of metals (Pb, Zn, Au, Ag, P, and Cu) and particulate matter play in causing bronchial hyperreactivity. Objectives: The purpose of the article was to measure the parameters of lung function as determined by body plethysmography, diagnosis of respiratory diseases, and assessment of respiratory function using a histamine bronchoprovocation test. Settings and Design: The present study was conducted in two groups of participants: A control group, which included 25 healthy persons, and a smeltery worker group, which included 45 mine workers (15 smokers and 30 nonsmokers) holding permanent jobs in the mineral foundry of Zvecan, Kosovo. Subjects and Methods: Pulmonary function parameters (specific airway resistance [Raw] and intrathoracic gas volume) were measured and used to calculate the specific resistance (SRaw)and specific conductance (SGaw) of the airways, and a histamine bronchoprovocation test was conducted. Statistical Analysis Used: The data were entered and analyzed using the Microsoft Excel and INSTAT 3 software. Results: Airway specific resistance (SRaw) was significantly higher in the smeltery worker group ( P < 0.01) as compared to the control group ( P > 0.1). Conclusion: These results suggest that occupational exposure to vapors during the metal refining process poses a risk to the workers' health and can cause bronchial hyperreactivity, bronchial asthma, or chronic obstructive pulmonary disease.