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Phencyclidine (PCP) in serum (5 ng/mL and higher) was quantitated by a homogeneous enzyme immunoassay procedure. Precision and accuracy data indicate that the procedure meets the requirements for a clinical assay. The short turnaround time for the assay makes it superior to other available methods for the emergency determination of PCP in serum. The analytical results were comparable to those by GC/MS on 70 samples tested. The serum concentration of PCP was determined in 500 specimens from 405 patients. In 216 patients with "pure" PCP intoxication, the serum concentration did not show a direct relationship to either the clinical pattern of intoxication or to the history of the route of PCP use.

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