Five cases of T-zone lymphoma were investigated with histologic, immunologic, and cytogenetic methods. The chromosome analyses were performed on lymphoma cells prepared immediately after removal of the lymph nodes. The chromosomes involved in structural rearrangements were nos. 1, 2, 3, 4, 14, and Y. Numbers 3, 5, 6, and 13 were lost by some tumors, and nos. 3 and 9 were gained. Chromosome 3 was involved most often in structural and numerical aberrations, whereas 14q + markers occurred in only one case. The importance of multidisciplinary studies is pointed out.
According to the current literature SLNE is recommended in primary tumors greater than 1 mm thickness. PET cannot be expected to give additional information in the staging of stage I-II patients.
The non-Hodgkin's lymphomas (NHL) occurring in children are described on the basis of the Kiel classification. As a rule, the NHL in children are of high-grade malignancy. The morphologic and immunologic features of all types of high-grade malignant B-cell lymphoma are described. The most frequent type of B-NHL in children is B-lymphoblastic lymphoma, including Burkitt and non-Burkitt types. Centroblastic lymphoma, immunoblastic lymphoma and unclassified high-grade malignant NHL are less common in children. The difference between the morphologic term "unclassified" and the immunologic definition "non-B/non-T" or "null" (or "unclassified") is explained. The equivalents of the various lymphoma types in the Lukes-Collins and Rappaport classifications are given.
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