Cytogenetic findings in T-zone lymphoma

Abstract

Five cases of T-zone lymphoma were investigated with histologic, immunologic, and cytogenetic methods. The chromosome analyses were performed on lymphoma cells prepared immediately after removal of the lymph nodes. The chromosomes involved in structural rearrangements were nos. 1, 2, 3, 4, 14, and Y. Numbers 3, 5, 6, and 13 were lost by some tumors, and nos. 3 and 9 were gained. Chromosome 3 was involved most often in structural and numerical aberrations, whereas 14q + markers occurred in only one case. The importance of multidisciplinary studies is pointed out.

The Comparative Diagnostic Features of Canine and Human Lymphoma

“…report that its unique immunophenotypic features may allow the diagnosis of cTZL to be made by flow cytometry alone [66]. According to the original Kiel classification scheme, hTZL is non-leukemic type of lymphoma containing all components of the T-regions of lymphoid tissue and can be considered as the diametric counterpart to follicular lymphoma [67]. Architecturally, in both canine and human, TZL is a non-effacing disease in which there is retention of B-cell follicles, including germinal centers, in the face of dramatic inter-follicular expansion owing to proliferating neoplastic T-cells (Figure 5) [67,68].…”

“…According to the original Kiel classification scheme, hTZL is non-leukemic type of lymphoma containing all components of the T-regions of lymphoid tissue and can be considered as the diametric counterpart to follicular lymphoma [67]. Architecturally, in both canine and human, TZL is a non-effacing disease in which there is retention of B-cell follicles, including germinal centers, in the face of dramatic inter-follicular expansion owing to proliferating neoplastic T-cells (Figure 5) [67,68]. Expansion of the interfollicular space by the neoplastic population results in displacement and compression of the residual follicles against a thinned perinodal capsule [66].…”

“…Cytologically, the neoplastic cells in similar in both canine and human TZL. In both species, they are small to medium-sized with a moderate amount of lightly stained cytoplasm and oval to elliptic nuclei with sharp, shallow indentations, finely granular chromatin, and inapparent nucleoli [67,69]. In both species, small numbers of large cells may be noted.…”

Morphologie, Immunhistochemie und Genetik peripherer T-Zellen-Lymphome

“…Untersuchungen mit den Genproben der a-und y-Kette liegen für T-Zellen-Lymphome noch nicht vor. Bei dem Vorgang des Rearrangement, das in jeder reifen TZelle erfolgt ist, werden DNA-Sequenzen aus verschiedenen Regionen (V, D, J, C der ß1 und ß2-Gruppen) des Der Einsatz der klassischen Zytogenetik bei T-Zellen-Lymphomen wurde in größerem Umfang bisher nur von Gödde-Salz durchgeführt [13,15,45]. Sie untersuchte Fälle von T-ZonenLymphom, Lymphogranulomatosis-X, lymphoepitheloidem Lymphom und Kil-Lymphom.…”

Report of the committee on chromosome changes in neoplasia

“…Germ (Gilbert ct al., 1982) (Frankeet al, 1985) Ip36-p32 deletions; translocations GL I (Rey ct al., 1987a) (R cyctal., 1987b(R cyctal., ) (Bigneret al, 1988) (Jenkins et al, 1989a) (Jenkins et al, 1989b) Ip36-p32 dcl(l)(p32-36) ML I (Godde-Salz et al, 1981) (Bloomfield et al, 1983) (Fukuhara et al, 1983) (Yunis et al, 1984) lp36 t( 1; 17)(p36;q21) AML-M3 II (Rowley et al, 1977b) (Yamada ct al., 1983) (Ohyashiki et al, 1985) (Schwartz et al, 1986) lp36 t( 1 ;3)(p36;q21) MDS; AML I (Moir ct al., 1984) (Bloomfield el al., 1985) (Viguic et al, 1986) lp36 t( 1; 1 )(p36;p 11-12) ML II (Reeves and Pickup, 1980) (Miyamoto et al, 1984) (Cabanillas et al, 1988 Ip34-p32 t(l;14)(p32-34;ql 1) T-ALL I (Mathicu-Mahul et al, 1986a) (Lamport et al, 1988) (Kaneko et al, 1989) (Seeker-Walker et al, 1989a) lp32 t( 1; 11 )(P32;q23) ALL I (Kaneko et al, 1986) (Hagemeijer et al, 1987) lp22-pl 1 deletions; translocations MEL I (Kakati et al, 1977) (Becher ct al., 1983) (Balaban et al, 1984) (Pedersen et al, 1986) (Parmitcret al, 1986 Ipl3-pl2 deletions; translocations LMS intestine I (Mark, 1976) (Sait ct al., 1988) (Mark et al, 1989) lp l3 -p l1 deletions; translocations AC breast I (Gcbhart et al, 1986) (Trent et al, 1987) lp l3 -p ll deletions; translocations MT pleura I (Gibas ct al., 1986) (Fujita et al, 1986) (Tiainen et al, 1988) 1 p 13 del( 1 )(p 13) ML I (Kaneko ct al., 1983…”