In subjects with symptomatic PAD, elevated baseline DD, a marker of thrombotic activity, was significantly associated with the occurrence of myocardial infarction. This study did not confirm a relationship between progression of PAD and baseline DD or CRP during the first 3 years. Baseline DD and CRP do not provide useful risk stratification in patients at high risk for progression of symptomatic PAD. Future studies should evaluate serial levels of these markers to assess their utility in predicting progression of symptomatic PAD.

Flow velocity varies widely within and among AxFBGs. Patency of AxFBGs is associated with higher midgraft PSV, and thrombosis with midgraft velocities less than 80 cm/s.

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Conclusions: This study demonstrates that CAS fractures are not associated with an increased risk of restenosis. The true incidence of stent fracture may be underestimated by x-ray analysis due to limited resolution and frequent artifacts. Additional methods to evaluate for subtle CAS fractures may assist in defining a more precise incidence and might lead to insight into the potential etiologies. Further evaluation with a larger study population and a longer follow-up both for stent integrity and its association with restenosis or adverse clinical outcomes is needed.