Zinc oxide nanocomposites in the form of coatings and composite films with antitumor activity were obtained by deposition of ZnO nanofilms on surfaces of ethyl ether Sali- cylidene DL-tyrosine (S1) and ethyl ether Sali- cylidene DL-tyrosine Cu (II) chelate (S2) by magnetron sputtering of Zn target. Ethyl ether salicylidene DL-tyrosine, Cu (II) chelate of ethyl ether salicylidene DL-tyrosine reveal some anticancer properties. Their zinc oxide nano- composites were obtained in the form of coat- ings (S1 + ZnO, S2 + ZnO) and composite films presenting a mixture of polyvinyl alcohol (PVA) with S1, S2 (S1 + PVA + ZnO, S2 + PVA + ZnO), for the purpose of increasing anticancer activity. Considerable increase in antitumor activity re- veal ZnO nanocomposites with salicylidene amino acid chelates (as distinct from their ethers) in the form of S2 + ZnO (47%) and S2 + PVA + ZnO (48%) in comparison with S2 (20%). Structural, spectral properties of the salicylidene amino acids and their ZnO nanocomposites were studied

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Изучены степени противосудорожной активности некоторых N-пара-замещенных производных γ-аминомасляная кислоты и их литиевых солей. Все исследованные соединения проявляют противосудорожную активность по антагонизму с коразолом и тиосемикарбазидом. Новые синтезированные производные ГАМК представляют биологическую ценность как новые нейротропные вещества, обладающие противосудорожными свойствами. / The degrees of anticonvulsant activity of some N-para-substituted derivatives of γ-aminobutyric acid and their lithium salts were studied. All studied compounds exhibit anticonvulsant activity in antagonism with corazole and thiosemicarbazide. Newly synthesized GABA derivatives are of biological value as new neurotropic substances with anticonvulsant properties.

The review focuses on a very peculiar aspect of the application of copper containing biologically active compounds of different chemical classes as have shown at the last scientific researches in the field of Cu (II) chelates, chelates possess have a higher activity of the same sort, than their mother compounds.The presented material shows essentially important qualities of Cu (II) containing compounds in biological aspect and has an interest for chemists, biochemists and pharmacologists.