sera prepared with residue RC (a residue deprived of its free lipids), the cells sensitized with the phosphatide antigens did not. Besides, as is clearly shown in Table 2, the phosphatide hemagglutination reaction was not at all inhibited by the tuberculin polysaccharides, and vice versa (3).The foregoing two facts clearly indicate that, in the animal body, the formation of antibodies to the bacillary phosphatide takes place independently of the formation of polysaccharide antibodies, at least so far as tuberculin polysaccharide is concerned.During the brief history of modern pharmacology few chemical entities have received such intensive investigation as nicotine. Langley's demonstration (1) in 1889 on the ability of nicotine to inhibit transmissions at synaptic junctions initiated a deluge of literally thousands of articles in the scientific literature.Several researchers have published on the physiological response of animals to nicotine as an index of neural development in the phylogenetic scale. Greenwood (2) reported that the toxic effect of nicotine on invertebrate organisms is sera prepared with residue RC (a residue deprived of its free lipids), the cells sensitized with the phosphatide antigens did not. Besides, as is clearly shown in Table 2, the phosphatide hemagglutination reaction was not at all inhibited by the tuberculin polysaccharides, and vice versa (3).The foregoing two facts clearly indicate that, in the animal body, the formation of antibodies to the bacillary phosphatide takes place independently of the formation of polysaccharide antibodies, at least so far as tuberculin polysaccharide is concerned. References and Notes 1. L. Negre, Les lipoides dans les bacilles tuberculeux et la tuberculose (Masson, Paris, 1950). 2. R. J. Anderson, Fortschr. Chem. org. Naturstoffe 3, 145 (1939). 3. The mechanism of phosphatide hemagglutination and its clinical meaning in tuberculosis are under investigation. 10 December 1957 Naunyn-Schmiedeberg's 199, 497 (1942). 7. P. S. Larson, J. K. Finnigan, H. B. Hoag, J. Pharmacol. Exptl. Therap. 95, 506 (1949). 8. The projectile-type hypodermic syringe and pneumatic rifle used in this study were kindly supplied
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