Toxicological studies of southeastern plants.II. Compositae

Duncan, Wilbur H.; Piercy, Paul L.; Feurt, Seldon D.; Starling, R.J.

doi:10.1007/bf02985332

Cited by 14 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All are found in the New World with the exception of B. halimifolia, which was introduced into Australia from the United States (Jarvis et al 1991). This species is suspected of poisoning cattle in both countries (Everist 1981) and proved toxic when administered experimentally to chicks (Duncan et al 1957). B. glomerulifolia, another North American species, was experimentally toxic to mice and chicks (Duncan et al 1957), and B. pteronioides has been associated with cattle poisoning in the southwestern United States (Marsh et al 1920, Stegelmeier et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…This species is suspected of poisoning cattle in both countries (Everist 1981) and proved toxic when administered experimentally to chicks (Duncan et al 1957). B. glomerulifolia, another North American species, was experimentally toxic to mice and chicks (Duncan et al 1957), and B. pteronioides has been associated with cattle poisoning in the southwestern United States (Marsh et al 1920, Stegelmeier et al 2009). B. pteronioides toxicosis was produced in hamsters dosed with 100-200mg of the plant (Stegelmeier et al 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

et al. 2012

View full text Add to dashboard Cite

Pesq. Vet. Bras. 32(5):383-390, maio 2012 383 RESUMO.-[Intoxicação experimental por Baccharis megapotamica var. weirii em búfalos.] As partes aéreas verdes de Baccharis megapotamica var. weirii foram administradas oralmente a cinco búfalos da raça Murrah de 6-8 meses de idade nas doses de 1, 3, 4, 5 e 10g/kg de peso corporal (pc) (~1-10mg de tricotecenos macrocíclicos/kg/ pc). A planta usada no experimento foi colhida numa fazenda onde um surto recente de intoxicação espontânea por essa planta havia ocorrido. Nos búfalos deste experimento, os sinais clínicos apareceram 4-20 horas e 4 búfalos morreram 18-49 horas após a ingestão da planta. Os sinais clíni-cos consistiram de apatia, anorexia, diarreia aquosa, febre, cólica, salivação, tremores musculares, inquietação, respiração laboriosa, atonia ruminal e desidratação. Five male 6-8 month-old Murrah buffalo calves were orally dosed with the fresh aerial parts of Baccharis megapotamica var. weirii at doses of 1, 3, 4, 5 and 10g/kg body weight (bw) (~1-10mg macrocyclic trichothecenes/kg/bw). The B. megapotamica used for the experiment was harvested on a farm where a recent spontaneous outbreak of poisoning caused by such plant had occurred. Clinical signs appeared 4-20 hours and 4 buffaloes died 18-49 hours after the ingestion of the plant. Clinical signs were apathy, anorexia, and watery diarrhea, fever, colic, drooling, muscle tremors, restlessness, laborious breathing and ruminal atony, and dehydration. The most consistent gross ϐindings were restricted to the gastrointestinal (GI) tract consisted of varying degrees of edema and reddening of the mucosa of the forestomach. Histopathological ϐindings consisted of varying degrees of necrosis of the epithelial lining of the forestomach and of lymphocytes within lymphoid organs and aggregates. Fibrin thrombi were consistently found in sub-mucosal vessels of the forestomach and in the lumen of hepatic sinusoids. It is suggested that dehydration, septicemia and disseminated intravascular coagulation participate in the pathogenesis of the intoxication and play a role as a cause of death. A subsample of B. megapotamica var. weirii was frozen-dried and ground and analyzed using UHPLC (Ultra High Performance Liquid Chromatography) with high resolution Time of Flight mass spectrometry and tandem mass spectrometry, it was shown that the plant material contained at least 51 different macrocyclic trichothecenes at a total level of 1.1-1.2mg/g. About 15-20% of the total trichothecenes contents was found to be monosaccharide conjugates, with two thirds of these being glucose conjugates and one third constituted by six aldopentose conjugates (probably xylose), which has never been reported in the literature.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

et al. 2012

View full text Add to dashboard Cite

show abstract

“…12 This species is suspected of poisoning cattle in both countries 9 and proved toxic when administered experimentally to chicks. 8 Baccharis glomerulifolia , another North American species, was toxic to mice and chicks 8 under experimental conditions, and Baccharis pteronioides has been associated with cattle poisoning in the southwestern United States. 18,26 Baccharis pteronioides toxicosis was produced in hamsters dosed with 100–200 mg of the plant.…”

mentioning

confidence: 99%

Baccharis megapotamica var. weirii poisoning in water buffalo (Bubalus bubalis)

et al. 2011

View full text Add to dashboard Cite

Abstract. An outbreak of an acute disease in buffalo (Bubalus bubalis) caused by the ingestion of Baccharis megapotamica var. weirii occurred in the southern region of Brazil. Ten out of 50 buffalo died 24-48 hr after being introduced into a pasture containing abundant amounts of the plant. Factors influencing the ingestion of the plant and consequent toxicosis included hunger, stress caused by shipment, and unfamiliarity with the plant. Clinical signs included serous ocular discharge, incoordination, mild bloat, and muscle trembling. One buffalo was necropsied. Gross findings included dehydration, abundant liquid in the rumen, reddening of the mucosa of forestomachs, abomasum, and intestine, and edema of the wall of the rumen. The main histologic lesions were superficial to full thickness degeneration and necrosis of the stratified epithelium lining the forestomachs, necrosis of the intestinal mucosa, and widespread lymphoid necrosis. A calf (Bos taurus) was fed a single dose of 5 g/kg/body weight of B. megapotamica var. weirii harvested from the same site where the buffalo died. Twenty hours after the administration of the plant this calf died with clinical signs and lesions similar to those observed in the naturally poisoned buffalo.

show abstract

“…Kze.) F. J. Hermann was known to produce a syndrome similar to nitro poisoning in chicks (5). Analysis of herbarium specimens of A. michauxii indicated the presence of nitro compounds.…”

Section: Discussionmentioning

confidence: 99%

Nitro Compounds in Foreign Species ofAstragalus

Williams¹

1981

Weed sci.

View full text Add to dashboard Cite

Leaflets of 1690 species of Old World and South AmericanAstragaluscollected from herbaria at Kew, England; Edinburgh, Scotland; Munich, Germany; and Vienna, Austria were analyzed qualitatively for toxic aliphatic nitro compounds. The catabolites of nitro compounds found in species ofAstragalus(nitro-bearing), 3-nitro-1-propanol and 3-nitropropionic acid, are especially toxic to cattle and sheep. A total of 190 of 1624 (12%) Old World species, 30 of66(45%) South American species, and a single species of oneAstragalussubgenus were positive for nitro compounds. Most Old World species that contained aliphatic nitro compounds were collected in the Middle East and the Union of Soviet Socialist Republics. Nitro compounds were detected in specimens of eight species collected between 1822 and 1836. The nitro-bearing species were chemotaxonomically related and grouped within taxonomic sections. The presence of two or three nitro-bearing species within a section indicated that other species within the same section might also be nitro-bearing.

show abstract

Toxicological studies of southeastern plants.II. Compositae

Cited by 14 publications

References 4 publications

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

Baccharis megapotamica var. weirii poisoning in water buffalo (Bubalus bubalis)

Nitro Compounds in Foreign Species ofAstragalus

Contact Info

Product

Resources

About