Highlights d Under basal conditions, most cAMP in cells is bound and its free concentration is low d Individual phosphodiesterases create nanometer-size domains of even lower cAMP d In such nanodomains, cAMP targets are protected from cAMP signals d Receptor stimuli increase cAMP to flood nanodomains and trigger downstream effects
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.