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We examined the relations between the Big-Five personality dimensions, Health Locus of Control, and health-related behaviours and attitudes. We focused on the question of potential advantages of the five-factor model as an integrated framework for personality and health research. Fifteen health habits and attitudes (including smoking, alcohol consumption, exercise, a variety of dietary practices, current stressors, and attitudes toward smoking and alcohol consumption) were used to operationalize the subjects' lifestyle. The study involved 1184 students from twelve different university schools. Although our results resembled those of other studies, we found that Conscientiousness and Agreeableness were particularly noteworthy as predictors of health behaviours and cognitive attitudes and tendencies. Our results also suggest that both factors should be included as explanatory constructs in personality± disease models that may indirectly affect disease proneness via unhealthy behaviours.