Background: The research evaluating adipokines are very few in patients with acne vulgaris. The hypothesis that hyperinsulinemic and high glycemic index diet plays a role in the pathogenesis of acne is still controversial. In this study, we aimed to evaluate adipokines such as leptin (L), adiponectin (A), ghrelin and A levels, and A/L rates that indicate insulin resistance in nonobese patients with severe acne vulgaris. Material and Method: Thirty patients who are nonobese with moderate acne vulgaris, aged 18 to 25 years, and 15 age–sex compatible controls were included in our study. The acne lesions were assessed using the Global Acne Grading Scale (GAGS). All participants were evaluated for the parameters that may affect the metabolism of serum L, A, and ghrelin levels in blood, and their body mass index were calculated. The significance level was determined as p ≤ 0.05. Results: Of the 30 patients, 17 were women and 13 were men. The mean age was 20.60 years and the mean duration of the disease were 2.8 years. All of patients had moderate acne vulgaris (GAGS 19–30). Of the 15 controls, 11 were women and 4 were men. The mean age was 21.20 years. There were not a statistically significant difference in L, ghrelin, A levels, and A/L ratio between the two groups. Conclusions: Adipokines may have a role in the pathogenesis of acne vulgaris. L, A, ghrelin, and insulin resistance may not participate in the responsible mechanisms in nonobese patients with moderate acne vulgaris.

The aim of this study was to evaluate changes in nasal and oropharyngeal flora in patients with acne during treatments with tetracycline and isotretinoin. Swab specimens were taken from the right and left nasal cavities and oropharynx of 55 patients with acne and 20 healthy volunteers who were admitted to the dermatology department (Etlik Educational and Research Hospital, Ankara, Turkey) before the administration of treatment and in the third month of treatment. Study participants were divided into four groups as follows: patients with acne on topical treatment only, systemic isotretinoin, and systemic tetracycline, and the control group. Of 55 patients with acne, 18 were male and 37 were female. The mean age of the patients and the control group was 22.21 ± 4.22 and 21.95 ± 7.64, respectively. Staphylococcus aureus was isolated from the nasal flora of five patients, normal flora was suppressed in the oropharyngeal cultures of seven patients, and normal flora grew in the cultures of the other 20 patients who were on tetracycline treatment. On the other hand, normal flora grew in the nasal and oropharyngeal cultures of all the patients who were on isotretinoin treatment. Treatment options and follow-up procedures for acne vulgaris may lead to the development of bacterial resistance and damage to flora. In particular, systemic tetracycline treatment leads to changes in flora of the nose and throat in patients with acne with an increased carriage of S. aureus. Therefore, careful attention should be paid to the duration of tetracycline treatment in order to not increase the risk of disturbance of microbial flora.

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Hizmet içi eğitim günümüzde çağı yakalayabilmek ve mesleki gelişimi artırabilmek için gerekli görülmektedir. Çalışanların görevini etkili ve verimli bir şekilde yerine getirebilmesi, eğitim, bilgi ve becerilerinin güncellemesi hizmet içi eğitim sayesinde olmaktadır. Bu araştırma, ortaokullarda görevli branş öğretmenlerine yönelik olarak düzenlenen hizmet içi eğitim faaliyetlerinin etkililiğini ve öğretmenlerin bu faaliyetlere ilişkin görüşlerinin belirlenmesini amaçlamaktadır. Araştırmada, nitel araştırma desenlerinden olgubilim kullanılmıştır. Veri toplama yöntemi olarak yarı-yapılandırılmış görüşme tekniği kullanılmıştır. 12 branş öğretmeni ile görüşme yapılarak veriler elde edilmiştir. Branş öğretmenleri Zonguldak, Batman, Düzce ve Hakkari'den seçilmiştir. Araştırmanın bulgularına göre, öğretmenlerin hizmet içi eğitim etkinliklerinin gerekli olduğunu, yalnız hizmet eğitimin verildiği zaman, veren kişiler ve verilirken kullanılan yöntem ve teknikler konusunda olumsuz tutuma sahip oldukları tespit edilmiştir. Araştırmaya katılan öğretmenlerin tamamı en az bir hizmet içi eğitim seminerine katıldıklarını belirtmişlerdir. Öğretmenler, yapılan hizmet içi eğitimlerden üst düzeyde bir yarar sağlanabilmesi için yeniliklere gidilmesi gerektiğini belirtmişlerdir. Araştırmada yer alan bulgular ışığında, hizmet içi eğitimlerin öğretmenlerin ihtiyacına ve eğitimin verileceği zamana dikkat edilerek yapılandırılması önerilmektedir.

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