Our results suggest that overexpression of CD44s could be relevant in determining the highly invasive behaviour of gliomas, though it does not behave as an independent prognostic factor for survival.

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The expression of E-cadherin and TIMP-2 could be relevant in determining the prognosis of CRC patients and providing a more accurate mechanism for their classification.

Background: CEACAM1, a novel target for cancer immunotherapy, is a member of the CEA family; it contains an immunoreceptor tyrosine-based inhibition motif (ITIM) in the intra-cytoplasmic domain. The ITIM motif appears to function in immune tolerance and immune exhaustion. Consequently, it plays a crucial role in inhibitory signals to immune cells. CEACAM1 is expressed on the membrane of T cells, NK cells, TILs, and tumor cells, and is known for the homophilic interaction with CEACAM1 expressed on tumor cells or immunocytes. We developed MG1124, a fully human monoclonal antibody against CEACAM1. abstracts Annals of Oncology Volume 31 -Issue S4 -2020 S725

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