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The present study examined the effects of cartilage oligometric matrix protein angiopoietin-1 (COMP-Ang1) on the revascularization of mice skin grafts. Full-thickness skin grafts were autotransferred into BALB/c mice. The donor grafts were soaked in COMP-Ang1 protein (50 g/ml, n ‫؍‬ 10) or in bovine serum albumin (BSA) (50 g/ml, n ‫؍‬ 10) dissolved in 1 ml of sterile, phosphate-buffered saline for 5 minutes before transfer. Revascularization of the grafts was monitored using an intravital microscope on postoperative days 3, 4, and 5. Morphological and immunohistochemical analyses were performed to evaluate platelet-endothelial cell adhesion molecule-1 and survivin expression and apoptotic signal in the transplanted grafts. Grafts soaked in COMP-Ang1 (COMP-Ang1 group) showed significantly increased revascularization compared with grafts soaked in BSA (BSA group) on intravital microscopy and plateletendothelial cell adhesion molecule-1 staining. The COMPAng1 group showed a significant increase of survivin expression in the endothelial cells and a reduction of apoptotic signal in comparison to the BSA group. Therefore, we believe that COMP-Ang1 provides the therapeutic benefit of enhancing the survival of vascular endothelial cells during transplantation of skin graft. (Am J Pathol

The small saphenous vein (SSV) is an important graft in limb salvage surgery. It is frequently translocated for bypass surgery. Sometimes, the use of the SSV as an in-situ graft for posterior tibial artery or peroneal artery reconstruction offers the advantages of reduced vein graft injury and improved patency. Recently, saphenous vein mapping through computed tomography (CT) volume rendering technique offers a great quality view to the surgeon. We experienced a patient in whom a CT image with volume rendering technique revealed an aberrant SSV connected with the great saphenous vein at the medial malleolus level. This case indicates that an aberrant SSV may be successfully used as an in-situ conduit for bypass to the dorsalis pedis artery. Here, we present the case of a popliteal-to-dorsalis pedis in-situ vein bypass using a LeMaitre valvulotome (LeMaitre Vascular Inc., USA) under mapping of the aberrant SSV by CT volume rendering technique.

Results: Among 13.3 million MEDLINE records identified during the study period, 0.35% of publications discussed AI. The frequency of AI publications in MEDLINE increased by 190% during the study period, from 0.16% in 2000 to 0.47% in 2016 (Fig). In 2016, the percentage of AI-related papers by therapeutic area was 0.49% for neurology, 0.32% for oncology, 0.31% for ischemic heart disease, and 0.18% for vascular disease. The increase in AI-related publications during the 17-year evaluation period was 451% for neurology, 306% for ischemic heart disease, 222% for oncology, and 147% for vascular disease. Conclusions: Utilization of AI for medical applications is growing rapidly. However, AI appears to be under-reported in vascular disease management. Future investigations will be needed for development of AI vascular disease applications including data digitization and data exchange and acquisition.

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