To determine the levels of serum total sialic acid (TSA) in patients with hyperemesis gravidarum (HG) and their gestational age-matched controls. Thirty pregnant women with HG, and 30 healthy pregnant women at up to 14 weeks of gestation were enrolled in this preliminary study. Total sialic acid levels in maternal serum were measured using the quantitative sandwich ELISA method. We observed statistically significant difference in TSA levels between HG and the control groups (p = .003). The identification of the role of SA in the prediction, diagnosis and follow-up of HG warrants more comprehensive studies in the future. Impact Statement What is already known on this subject? The derivatives of neuraminic acid are collectively referred to as sialic acid (SA). Changes in SA levels are known to trigger various conditions and disorders, including inflammatory, cardiovascular, neurological and endocrine diseases. Although a sensitive test capable of identifying hyperemesis gravidarum (HG) would be useful for diagnosis purposes, such a test is currently not available. Studies focussing on identifying new potential indicators and biomarkers for HG - as well as identifying their relevance in establishing diagnosis and assessing disease severity - would not only assist in elucidating the underlying causes of this condition but would also contribute to the development of new diagnostic tests for HG. What the results of this study add? Total sialic acid levels are significantly higher in sera of the patients with HG. The present study is the first in the literature to assess total sialic acid levels in patients with HG and healthy pregnant women before 14 weeks of gestation. What the implications are of these findings for clinical practice and/or further research? Total sialic acid levels could give an idea to clinicians in the etiopathogenesis of HG. The identification of the role of sialic acid in the prediction, diagnosis and follow-up of HG warrants more comprehensive studies in the future.

Bu çalışma, sağlık hizmetleri meslek yüksekokulu öğrencilerinin kardiyovasküler hastalıkların risk faktörlerine yönelik bilgi düzeylerini ve bilgi düzeylerinin bazı değişkenlere göre farklılık gösterip göstermediğini belirlemek amacıyla yapıldı. Tanımlayıcı olarak yapılan çalışmanın örneklemini bir devlet üniversitesinin sağlık hizmetleri meslek yüksekokulunda öğrenim gören 851 öğrenci oluşturdu. Veriler, Tanıtıcı Bilgi Formu ve Kardiyovasküler Hastalıklar Risk Faktörleri Bilgi Düzeyi (KARRİF-BD) Ölçeği ile toplandı. Verilerin istatistiksel analizinde One Way Anova, t-testi, Kruskal Wallis varyans analizi ve Mann Whitney U analizi kullanıldı. Araştırmadaki öğrencilerin yaş ortalaması 20.43±1.90 yıl olup KARRİF-BD ölçeği puan ortalaması 18.05±5.07'dir. Acil ve ilk yardım programında öğrenim gören, il merkezinde yaşayan, sosyal güvencesi olan, geliri giderine eşit, kronik hastalığı olan ve ailede kalp damar hastalığı bulunan öğrencilerin puan ortalamasının önemli bir şekilde yüksek olduğu tespit edildi (p<0.05). Araştırma sonuçları sağlık hizmetleri meslek yüksekokulunda öğrenim gören öğrencilerin kardiyovasküler hastalık risk faktörlerine ilişkin bilgi düzeylerinin orta düzeyde olduğunu ve öğrenim gördüğü bölüm, yaşadığı yer, sosyal güvencesinin olması, ekonomik durum, kronik hastalık bulunma ve ailede kalp damar hastalığı varlığı değişkenlerine göre farklılık gösterdiğini göstermektedir. Bu kapsamda öğrencilere kardiyovasküler hastalık risk faktörleri hakkında daha fazla bilgi verilmesi önerilmektedir.

Objective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in patients with first trimester miscarriage. Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and 35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdG levels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDA levels were also measured in both groups. Results: There wasn't difference in terms of complete blood count, thyroid-stimulating hormone (TSH), homocysteine values, parity, age, body mass index (BMI) and gestational age between the groups. Serum 8-OHdG and MDA levels were significantly higher in the patient group (p=0.001). A moderate positive significant correlation between the gestational week and MDA values and a weak but significant positive correlation between 8-OHdG values and gestational week were detected in the patient group.