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In this project, Ni(II) ion stabilized on zeolite-Y (NNZ) was developed as a high efficient nanoporous catalyst for the synthesis of 3-benzimidazolyl-1,3-thiazolidin-4-one derivatives via condensation of 2-aminobenzimidazole, aromatic aldehydes and thioglycolic acid in ethanol under ambient conditions. Compared with conventional protocols, this methodology has promising features such as the use of inexpensive, stable, recyclable and safe catalyst, shorter reaction times and higher yields, nontoxic solvent and easy isolation of the products.

silica boron sulfonic acid (SBSA) was easily prepared and used as a new and efficient solid acid catalyst for the synthesis of benzimidazole derivatives with high isolated yields. Various substituted benzimidazoles were synthesized by a combination of o-phenylenediamines and aldehydes in the presence of boron sulfonic acid in with good yields in water and under a mild reaction conditions. This method is also applicable for precursors such as: aromatic and unsaturated aldehydes and o-phenylenediamines.

Merrifield Resin was functionalized with metformine and applied as a solid support to immobilize the CuCl2. The Ps‐Met/CuCl2 was characterized by several techniques including Fourier transform infrared (FTIR), field emission scanning electron microscopy (FESEM), energy‐dispersive X‐ray spectroscopy (EDX), wavelength‐dispersive X‐ray spectroscopy (WDX) and inductively coupled plasma (ICP). The Ps‐Met/CuCl2 was used as an efficient recyclable solid nanocatalyst for N‐arylation of indole and aniline through coupling reactions of Ullmann‐type C‐N. The advantages of this method are easy workup, improved yields, and simple recovery via filtration. Ultimately, the Ps‐Met/CuCl2 antibacterial property was examined against two bacteria (Staphylococcus aureus (Staph. aureus) and Escherichia coli (E. coli)) and indicated its antibacterial performance against gram negative (E. coli) bacteria and gram positive (Staph. aureus).

A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1,2-diamines with α-diketones in the presence of catalytic amount of phenol(20 mol%) at room temperature is described. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times.