This study aimed to show the impact of learning strategies based on each multiple intelligences domain(analytical, introspective and interactive) on learning in blended learning.Thirty third-year computer science students in vocational high schools in Isfahan were randomly assigned to experimental and control groups (15 in each). The previous semester Average scores and multiple intelligences profiles were measured and were similar in both groups. Two groups were trained in 4 sessions (each 70 minutes) in the way of blended learning. In addition, the experimentalgroup used an electronic content based on multiple intelligences. The Pre-test and the post-test (before and after training) were the same in both groups. The Data were analyzed using SPSS-19 software by Chi-square test and independent samples ttest. The independent samples t-test on addend scores meaningfully shows more learning achievements for students who used E-Content based on multiple intelligences in introspective domain (P=0.014).