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Prolene mesh used in hernia repair caused increased inflammation and fibrosis and effected latency and denervation negatively. Single dose methylprednisolone administration decreased nerve damage and inflammation. On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.

Background/Aims: Inflammatory bowel disease (IBD) is a chronic, relapsing, and remittent inflammatory disease of the gastrointestinal tract. Nutritional deficiency may be instrumental and contributable in this disease, among which vitamin B12 deficiency has been identified in IBD. Since the relationship between vitamin B12 and IBD remains controversial, in this study, we have examined the effect of vitamin B12 supplementation on acetic acid (AA)-induced colitis in rats. Methods Total of 28 rats were randomized into four groups of seven animals per group; Group 1 (Control saline) was the control group, group 2 (AA colitis control) was the disease control group, group 3 (VitB12) was the vitamin B12 alone treatment group, group 4 (VitB12 treatment in AA colitis) was the AA-induced colitis VitB12 treatment group. Weight change was measured. Macroscopic and microscopic scores were measured in each group. Tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, myeloperoxidase (MPO), malondialdehyde (MDA), glutathione reduced (GSH), and superoxide dismutase (SOD) were measured in each group. Results Macroscopic scores, as well as microscopic scores, were not different between the group. Also, the levels of TNF-α, IL-1β, MPO, MDA, and SOD did not differ between AA control and VitB12 treated AA colitic group. However, the levels of IL-6 and GSH were significantly different in rats with AA-induced colitis after vitamin B12 injection. Conclusion Nutritional deficiencies might contribute to the pathogenesis of IBD, but in this study, the efficacy of vitamin B12 supplementation has controversial effects on the intestinal mucosa.

It is known that physical activity plays a cardioprotective role. Various types of physical exercise have positive effects on the plasma lipid panel, which generally indicates the risk of cardiovascular disease. The aim of this study is to examine the plasma lipid levels of elite volleyball players who trained heavily for 10 weeks. Male elite volleyball athletes voluntarily participated in the study, who are healthy and between the ages of 18-35 (n=18). Body mass index (BMI) values were calculated by measuring the weight and height of all athletes participating in the study before and after heavy exercise. Before and after the heavy exercise program, blood plasma samples were taken from the athletes for biochemical and hematological analyzes. When the plasma values of the athletes were compared before and after exercise, no statistically significant difference was found (p>0.05). It was determined that the total cholesterol (TC) value in the plasma lipid panel of the athletes after heavy exercise decreased (p

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