No abstract

In this research, the synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines by CuFe2O4/KCC‐1/PMA magnetic nanoparticles was reported. Synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines was performed under solvent‐free conditions with good to excellent yields. The prepared nanocatalyst was synthesized in three steps and also was characterized by Fourier transform infrared (FT‐IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD), vibrating sample magnetometry (VSM), and N2 adsorption–desorption measurement (Brunauer–Emmett–Teller [BET]) analyses. In addition, the reusability studies of CuFe2O4/KCC‐1/PMA showed that the recovered catalyst could be used for several times.

No abstract

N-((2-hydroxynaphthalen-1-yl)(4-nitrophenyl)methyl)acetamide (5a)

The synthesis of deuterated chlorhexidine hydrochloride is reported. The specific labelling of the saturated chain is achieved through the combination of the previously reported synthesis of 2,2,3,3,4,4,5,5-( 2 H 8 )-hexane-1,6-diol and a synthesis of carbon-14 labelled chlorhexidine. This synthesis begins with commercially available hex-2,4-yne-1,6-diol, its protection as a bis-tetrahydropyranylether, and exhaustive deuterogenation under rhodium catalysis to produce, after acid hydrolysis of the protecting groups, the saturated octadeuterated 1,6-hexanediol. Conversion of this material in two steps to the corresponding 1,6-diaminohexane was followed by the generation of guanidines with dicyanimide and final condensation with p-chloroaniline. The title compound was obtained in 10 chemical steps and in 6% overall yield.