Background: This study aimed to document early left ventricular (LV) dysfunction in chronic kidney disease (CKD) using methods such as tissue Doppler imaging and the myocardial performance index (MPI). Methods: A total of 40 patients diagnosed with CKD (mean age, 10.1 AE 4.1 years) and 40 sex-and age-matched healthy controls (mean age, 9.6 AE 4.3 years) were examined. In the patient group, 20 patients had early stage (Stage 2-3) CKD and 20 patients had late-stage (stage 4-5) CKD, and 18 patients had hypertension. Results: The pulmonary artery systolic pressure (PAPs) and LV mass index (LVMI) were significantly higher in the patient group (P < 0.05). The LV septal and lateral margins of the mitral annulus E'/A' ratio, E/E' ratio and MPI results were significantly different between the groups (P < 0.05). The MPI scores were higher in late-stage CKD than in early stage CKD (P < 0.05). The E'/A' ratio was lower and the MPI was higher in the hypertensive CKD group compared with the normotensive CKD group (P < 0.05). The E/E' ratio was correlated positively with the LVMI, and the PAPs, and negatively with glomerular filtration rate, S' value, E'/A' ratio. The MPI was correlated positively with blood pressure, LVMI, PAPs, and the S value, and negatively with the E'/A' ratio. Conclusions: The E'/A' ratio, the E/E' ratio, and the isovolumetric relaxation time measured by tissue Doppler imaging is highly accurate and easily applicable for detecting diastolic LV function, and the MPI is suitable for detecting both systolic and diastolic LV dysfunction. Their routine use may be useful in evaluating LV functions in children with CKD.

Doğum sonrası süreçte sıklıkla yenidoğan geçici taşipnesi ve konjenital kalp hastalığı ön tanıları nedeniyle geç tanı alabilen ve orta-ağır pulmoner hipertansiyonun eşlik ettiği vakalarda Galen ven anevrizması (GVA) riskine dikkat çekmeyi amaçladık. Yöntem: GVA tanısıyla merkezimizde takip ve tedavisi yapılan vakalar çalışmaya alındı. Vakaların doğum şekli, doğum haftası, doğum boy-kilo-baş çevresi, yapılan medikal tedaviler ve görüntülemeler hasta dosyasından kaydedildi. Bicetre skoruna göre yapılan risk değerlendirmesi kaydedildi. Bulgular: Vakalarımızın %80'i kız (n=4) olup, %80'i (n=4) spontan vajinal yol ile doğurtuldu.

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