Background Most case series of patients with ischemic stroke (IS) and COVID‐19 are limited to selected centers or lack 3‐month outcomes. The aim of this study was to describe the frequency, clinical and radiological features, and 3‐month outcomes of patients with IS and COVID‐19 in a nationwide stroke registry. Methods From the Swiss Stroke Registry (SSR), we included all consecutive IS patients ≥18 years admitted to Swiss Stroke Centers or Stroke Units during the first wave of COVID‐19 (25 February to 8 June 2020). We compared baseline features, etiology, and 3‐month outcome of SARS‐CoV‐2 polymerase chain reaction‐positive (PCR+) IS patients to SARS‐CoV‐2 PCR− and/or asymptomatic non‐tested IS patients. Results Of the 2341 IS patients registered in the SSR during the study period, 36 (1.5%) had confirmed COVID‐19 infection, of which 33 were within 1 month before or after stroke onset. In multivariate analysis, COVID+ patients had more lesions in multiple vascular territories (OR 2.35, 95% CI 1.08–5.14, p = 0.032) and fewer cryptogenic strokes (OR 0.37, 95% CI 0.14–0.99, p = 0.049). COVID‐19 was judged the likely principal cause of stroke in 8 patients (24%), a contributing/triggering factor in 12 (36%), and likely not contributing to stroke in 13 patients (40%). There was a strong trend towards worse functional outcome in COVID+ patients after propensity score (PS) adjustment for age, stroke severity, and revascularization treatments (PS‐adjusted common OR for shift towards higher modified Rankin Scale (mRS) = 1.85, 95% CI 0.96–3.58, p = 0.07). Conclusions In this nationwide analysis of consecutive ischemic strokes, concomitant COVID‐19 was relatively rare. COVID+ patients more often had multi‐territory stroke and less often cryptogenic stroke, and their 3‐month functional outcome tended to be worse.

No abstract

Zusammenfassung. Bei der transienten globalen Amnesie (TGA) handelt es sich um eine klinische Diagnose mit typischen Zeichen einer akuten, anterograden und retrograden Amnesie. Die Ursache ist bisher ungeklärt, verschiedenen Hypothesen werden diskutiert. Letztlich handelt es sich um eine passagere Funktionsstörung im Bereich der Hippocampi. Hierzu korrelierend findet man gehäuft in der DWI-Sequenz im MRI eine kleine, punktförmige Signalhyperintensität im Hippocampus, die in Verlaufsuntersuchungen nicht mehr darstellbar ist. Diese können uni- oder bilateral auftreten. Es existiert keine spezifische Therapie, eine Sekundärprophylaxe ist nicht indiziert. Die Prognose ist gut. Das Rezidivrisiko beträgt ca. 18%.