Chronic periodontitis is associated with coronary heart disease (CHD), including Acute Coronary Syndrome (ACS), which causes inflammation. CRP, IL-6, leukocytes, neutrophils, and lymphocytes are inflammatory mediators. This study aimed to evaluate CRP, IL6, leukocytes, and NLR effect on chronic periodontitis in ACS patients. A total of 60 ACS patients who underwent coronary angiography were used in this study. Coronary artery assessment was measured based on QCA coronary angiography. Periodontal status measured were Oral Hygiene Index (OHI-S), Bleeding on Probing (BOP), and Periodontal Index (PI). The normal-mild limit values of chronic periodontitis were periodontal depth (PD) <4mm, while the moderate-severe of chronic periodontitis was PD ≥ 4 mm. Correlation of CRP, IL-6, leukocytes, and NLR to chronic periodontitis was determined by the Spearman correlation test, followed by path analysis using smartPLS software version 3.0. Additionally, the Goodness of Fit analysis and logistic regression was also conducted. Moderate-severe and normal-mild of chronic periodontitis were found in 45 patients (75%) and 15 patients (25%), respectively. OHI-S, BOP, and PI in moderate-severe chronic periodontitis were significantly higher than in the normal-mild chronic periodontitis group (p<0.05). A comparison of CRP, IL-6, leukocytes and NLR showed no significant value (p>0.05) in both groups. There was no significant positive relationship between CRP, IL-6, leukocytes, and NLR with chronic periodontitis. No direct effect of CRP, IL-6, leukocytes and NLR on chronic periodontitis was found, but female sex and smoking directly affected chronic periodontitis (p<0.05). Female and smoking patients had a higher risk of developing more severe chronic periodontitis with a female OR value of 6.916 (95% CI: 0.470 – 101.798), while the OR smoking was 10.759(95% CI: 1.064 – 108.762). ACS patients were dominated by moderate to severe chronic periodontitis and had worse OHI-S, BOP, and PI. There were no significant effects of CRP, IL-6, leukocytes, and NLR on chronic periodontitis. Our findings revealed a significant direct effect and a high risk of female sex and smoking against chronic periodontitis on ACS patients.

ABSTRAKPendahuluan: Periodontal abses dapat menyebabkan migrasi gigi patologis (ekstrusi) dan defek intraoseus. Pada kondisi ini perawatan ortodontik-periodontik merupakan pendekatan terapeutik yang dapat memposisikan kembali gigi yang telah mengalami migrasi patologis dan memperbaiki kondisi periodontal. Terapi multidisiplin sangat penting dalam praktik kedokteran gigi untuk mencapai hasil yang optimal. Tujuan laporan kasus ini adalah untuk menggambarkan pendekatan bidang ortodontik-periodontik  pada perawatan migrasi gigi patologis. Laporan kasus: Laki-laki, 35 tahun dengan keluhan utama gigi inisisivus kanan atas abses, goyang, dan nyeri. Secara klinis pada gigi 11 terdapat kegoyangan derajat tiga, poket periodontal bagian mesial 7mm, resesi 3mm, dan kontak prematur pada gigi 41. Pemeriksaan radiografi terlihat kerusakan tulang yang parah. Penatalaksanaan kasus, pada kunjungan pertama, pemberian medikasi oral sebagai terapi darurat, kunjungan kedua adalah scaling dan root planing, occlusal adjustment, dan splinting pada kunjungan ketiga. Kemudian pemasangan ortodontik cekat pada rahang atas dilakukan pada kunjungan berikutnya, untuk mengembalikan posisi gigi insisivus lateral yang ekstrusi. Setelah mencapai posisi yang sesuai, dilakukan bone graft pada gigi. dapat mengembalikan posisi gigi yang mengalami ekstrusi, mengurangi kegoyangan gigi dan mengembalikan fungsi estetik pasien. Simpulan: pendekatan bidang ortodontik-periodontik pada perawatan migrasi gigi patologis menunjukkan keberhasilan setelah kontrol enam bulan pasca bedah ditandai dengan gambaran panoramik adanya penambahan densitas serta tinggi tulang yang signifikan pada daerah defek, gigi insisivus sentral atas kembali ke posisi normal dan kepuasan pasien tercapai.

Background: Midline diastema in the maxillary is very common aesthetics problem in mixed and early permanent dentition, one of which etiology is aberrant frenum attachment. High frenum attachment might interfere with aesthetics, plaque control, and create mucogingival deformities, therefore compromising orthodontic result and causing recurrence. Several treatments for maxillary midline diastema are available, one of which is labial frenectomy. Objective: To present a case report of frenectomy as a mean of eliminating maxillary midline diastema. Case: This is a case report of a 25 years old female patient with high frenum attachment causing maxillary midline diastema. Patient was treated with frenectomy afterward. Frenectomy is a complete removal of frenum, including the attachment to the underlying bone. Following the treatment, midline diastema closure was showed in 4 months following frenectomy. Conclusions: Frenectomy is a potential alternative for treatment of maxillary midline diastema.

Background: The tissue engineering technique to bone and periodontal tissue regeneration therapy that makes use of one or more of three key factors: signaling molecules, scaffold or supporting matrix, and cells. The graft works as a scaffold and a framework for forming a structure to aid tissue regeneration. One of the most generally used graft substances is hydroxyapatite (HAp). Hydroxyapatite (HAp) is a calcium phosphate derivative that is commonly utilized in bone coatings and cements due to its exceptional biocompatibility. The topic of nano- hydroxyapatite (nHAp) in tissue regeneration therapy will be discussed in this publication. Methods: The method used in writing this article review was a literature review sourced from Google Scholar, Science Direct, and PubMed (MEDLINE). Result: The identification results from a search on Google Scholar, Science Direct, and PubMed (MEDLINE) in which the title contains one or more keywords being searched for, from the article, 55 articles are obtained that have appropriate titles and 14 data are obtained from the results of the review. Discussion: Hydroxyapatite (HAp) is a bioceramic material formed from strong chemical bonds and is included in the bone components of living organisms (in vivo). Conclusion: Hydroxyapatite (HAp) is a bioceramic substance made up of a strong chemical link that is a derivative of calcium phosphate. It is commonly used in coatings or cements on bone because of its excellent biocompatibility.