No abstract

months [55-351months], three times a week, four hours each session, with blood pump flow at 300ml/min and dialysate fluid flow at 500ml/ min. Eleven patients were dialysate with high flux membrane, four with medium flux membrane. Symptoms at time of the endocrine check were: severe hypoglycemia in 3 cases, chronic hypotension in 7cases, severe weakness in 8 cases.The mean hormones levels and intervals are summarized in figure1.We noticed peripheric hypothyroidism in 3 patients, moderate hyperprolactinemia in 7 cases, hypergonatrophic hypogonadism in3 cases and hypogonadotrophic hypogonadism in 2 cases.One patient presents an anterior pituitary deficiency with three axes affected (hypogonadotrophic hypogonadism, central adrenal deficiency and central hypothyroidism). All abnormalities found were treated with replacement hormonal therapy. We noticed an improvement in the initial symptomatology in all cases. Conclusions: As kidney function declines, sexual hormones, the hypothalamic-pituitary axis, and the thyroid frequently function aberrantly. The pathogenesis of those disorders is multifactorial, with extrinsic and intrinsic factors. Their screening in hemodialysis patients must be early because of the added risk of many complications' occurrence. Their management requires multidisciplinary approach.