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The imaging speed of optical resolution photoacoustic microscopy (OR-PAM) using pulsed excitation is fundamentally limited by the range ambiguity condition, which defines the maximum laser pulse repetition frequency (PRF). To operate at this theoretical upper limit and maximize acquisition speed, a custom-built fiber laser capable of operating at a PRF of up to 2 MHz was combined with a fast laser scanning optical OR-PAM system based on a stationary fiber-optic ultrasound sensor. A large area (10 mm × 10 mm) of the mouse ear was imaged within 8 s, when acquiring 16 million A-lines and operating the laser at a PRF of 2 MHz. This corresponds to a factor of four improvement in imaging speed compared to the fastest OR-PAM system previously reported. The ability to operate at high-imaging frame rates also allows the capture of hemodynamic events such as blood flow. It is considered that this system offers opportunities for high throughput imaging and visualizing dynamic physiological events using OR-PAM.

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We present results on a high-power, cladding-pumped, Yb-doped fiber emitting at 977 nm in laser and ampllified-spontaneous-emission source configurations. We obtained up to 1.4 W of fiber-coupled, single-mode output power and slope efficiency as high as 68%. To our knowledge these are the highest powers efficiencies achieved from a single-mode fiber laser at approximately 980 nm and the first demonstrated results on a high-power amplified-spontaneous-emission source in this wavelength range. High power and high slope efficiency are achieved by using a high numerical aperture (> 0.7), a jacketed air-clad fiber, and a high-brightness pump source. Both types of sources exhibit relative intensity noise below -130 dB/Hz and are thus suitable for a wide range of applications.

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