BackgroundThe present study sought to investigate the effects of Tarantula cubensis extract (TC; Theranekron®) on the histopathological scores of peritoneal wound healing after laparotomy in the rats.MethodsThis study was designed to investigate the effects of Theranekron on the peritoneal wound healing after wound creation, on days9, 14, 19, 24 and 29 post-injury in rats. Twenty-four mature Wister-albino male rats were randomly divided into two groups. In the experimental group, TC was repeatedly injected subcutaneously (SC) over the lesion 9, 14,19 and 24 days after laparotomy, whereas the control group received only normal saline by subcutaneous injection and then the animal groups were euthanized9, 14, 19, 24, and 29 days after wounding respectively by intravenous injections of pentobarbital (50 mg/kg). Finally, assessment of the peritoneal wound healing between the groups was carried out by histopathologic data and statistical tests as Mann-Whitney U, Wilcoxon W and ZResultsHistopathological examination indicated significant improvement in angiogenesis, re-epithelialization and less inflammatory response in comparison to control and also, revealed matured, compact and parallel deposition of collagen fibrils on day 29. So, at long term, treatment reduced the inflammation and increased the quality and rate of wound re- epithelialization compared to controls(P < 0.05). Furthermore, excluding the control group, rats exhibited the most pronounced effect on wound closure, with the statistically significant improvement in wound healing being seen at post-operative day 29. Moreover, collagen content on days 24 and 29 in the test group was found to be higher than in the healthy group. To warp up, treated groups had a significant increase in peritoneal wound healing area compared to the control group on all days (P < 0.05).ConclusionsOur results suggested that Theranekron have delivered a novel therapeutic route for wound treatment in clinical practice.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2958770714954315.

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Osteoporosis in elderly is a worldwide problem with high cost on health care systems Prevention of osteoporosis and its associated fractures, improves quality of life, and reduces the financial burden of treatment costs. Standard treatment regimen includes bisphosphonate, calcium, and Vitamin D3. In this paper we have studied the effect of daily administration Vitamin C on osteoporosis improvement. We studied 66osteopenic to osteoporotic (T score <-1) patients referred to IMAM REZA hospitalduring 2012-2014 years . Cases were randomized in two groupsof 33 patients. Both control and trial group were treated for osteoporosis with a regimen composed of alendronate 70mg weekly, 3 calcium carbonate (500mg) tablets per day and parenteral Vitamin D3 injection once a month. Thetrial group also received one Vitamin C tablet (250 mg) per day. Patient were followed for at least 12 month. After one year of treatment bone marrow density (BMD) was evaluated again. There was no statistically significant difference between controls and the trail group at the beginning of the studyregarding demographic (age, weight, and height) and BMD.After one year of treatment the trial group, showed significantly better BMD than the control group(p<0.05). Addition of Vitamin C improves the outcome of osteoporosis.This is as safe and a low cost addition to standard treatment.