Background: Biotin has gained commercial popularity for its claimed benefits on healthy hair and nail growth. Despite its reputation, there is limited research to support the utility of biotin in healthy individuals. Objective: To systematically review the literature on biotin efficacy in hair and nail growth. Methods: We conducted a PubMed search of all case reports and randomized clinical trials (RCTs) using the following terms: (biotin and hair); (biotin and supplementation and hair); (biotin supplementation); (biotin and alopecia); (biotin and nails); (biotin and dermatology), and (biotin recommendations). Results: We found 18 reported cases of biotin use for hair and nail changes. In all cases, patients receiving biotin supplementation had an underlying pathology for poor hair or nail growth. All cases showed evidence of clinical improvement after receiving biotin. Conclusions: Though its use as a hair and nail growth supplement is prevalent, research demonstrating the efficacy of biotin is limited. In cases of acquired and inherited causes of biotin deficiency as well as pathologies, such as brittle nail syndrome or uncombable hair, biotin supplementation may be of benefit. However, we propose these cases are uncommon and that there is lack of sufficient evidence for supplementation in healthy individuals.

The predominant bacteria in microbiome studies of adult acne is Propionibacterium, whereas in this pediatric population we saw a lot of Streptococcus bacteria. After treatment, the microbiomes of intervention group participants more closely resembled those of control group participants.

Lesbian, gay, transgender/gender diverse, questioning/queer, intersex, and asexual (LGBTQIA) patients represent an underserved population in medicine. While literature surrounding this group is becoming more prominent, the role dermatologists play in their care is evolving. For example, transgender patients experience unique cutaneous side effects secondary to medications while undergoing transition including testosterone, estrogen, and antiandrogens. 1 Additionally, transgender patients often seek both invasive and noninvasive procedures for gender affirmation. [1][2][3] While dermatologic care for adult transgender patients is more established, studies in the pediatric transgender population are very limited. 1 Understanding the appropriate terminology and definitions of transgender care is also critical (Table 1). Herein, we review dermatologic considerations for transgender patients, highlighting the role pediatric dermatologists can play in their care while emphasizing the need for further studies in pediatric and adolescent transgender populations.

Diagnosis of LAS should be made based on history, microscopic findings, and hair bulb and shaft features.