The growth rate of agricultural production is reducing worldwide every year due to mainly biotic and abiotic stresses including plant diseases. Various organic and inorganic methods are being used to protect plants from disease causing pathogens. Among them, use of pesticides is the most prevalent one incurring millions of dollars on pesticides globally for control of plant diseases. In recent years, environmental hazards and ill effects caused by indiscriminate use of pesticides have been widely discussed. Therefore, agriculture scientists are finding an alternative antimicrobial compounds such as nanoparticles for the management of diseases with least adverse effect on nature and ecosystem. Herein we reviewed the synthesis, antimicrobial efficacy and compatibility of silver nanoparticles which could help to develop the novel technology for crop protection.