Background: Filopodium formation is a prerequisite for neurite initiation. Results: SH2B1 interacts with IRSp53 and promotes neurite outgrowth of hippocampal neurons. Conclusion: SH2B1-IRSp53 complexes promote filopodium formation, neurite initiation, and neurite branching. Significance: These results suggest that SH2B1 may regulate the formation of filopodia required for many cellular functions.
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