We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival. A comprehensive search of the PubMed and EMBASE was performed from the inception to September 30, 2016. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model. Ten studies, with a total of 31,210 breast cancer cases, were included in the meta-analysis. The summary HRs (95% CIs) of overall survival (highest vs. lowest) were 1.08 (0.88–1.33; I2 = 41.1%) for pre-diagnostic intake of vegetables and fruits combined, 0.96 (0.71–1.30; I2 = 48.4%) for vegetables alone, and 0.83 (0.67–1.02; I2 = 0) for fruit alone. No significant risk associations of overall survival were found for post-diagnostic intake of vegetables and fruits. Line dose-response analyses indicated the likely results for both pre- and post- diagnostic dietary intake. No significant association was found between intake of vegetables and fruits and breast cancer-specific mortality. In addition, intake of cruciferous vegetables was not associated with death from breast cancer. Our findings indicated a borderline inverse association between pre-diagnostic intake of fruit and overall survival of breast cancer, whereas intake of vegetables was not associated with survival.
BackgroundThere have been inconsistent results about the association between consumption of fruits and vegetables and renal cell carcinoma (RCC) risk. We conducted a meta-analysis of the published observational studies to explore this association.ResultsNineteen observational studies (4 cohort, 1 pooled and 14 case-control studies), involving 10,215 subjects with RCC were part of this meta-analysis. The SRR for the highest vs. the lowest intake of vegetables was 0.73 (95% CI: 0.63–0.85; Pheterogeneity = 0.004, I2 = 53.5%), whereas for fruits it was 0.86 (95% CI: 0.75–0.98; Pheterogeneity = 0.012, I2 = 47.4%). Linear dose-response analysis also showed similar results, e.g., for per 1 serving/day increment of vegetables, the SRR was 0.90 (95% CI: 0.84–0.96) and for fruits it was 0.97 (95% CI: 0.93–1.01). Nonlinear association was only observed for vegetables (Pnonlinearity = 0.001), but not for fruits (Pnonlinearity = 0.221).Materials and MethodsEligible studies up to August 31, 2016 were identified and retrieved by searching MEDLINE and EMBASE databases along with manual review of the reference list from the retrieved studies. Quality of included studies was evaluated using Newcastle-Ottawa Quality Assessment Scale (NOS). Random-effects model was used to calculate summary relative risk (SRR) and corresponding 95% confidence interval (CI).ConclusionsThis meta-analysis indicated a protective effect of consumption of vegetables and fruits on RCC risk. Further studies are warranted with prospective designs that use validated questionnaires and control for important confounders.
BackgroundFindings on the association between intake of red and processed meat with renal cell carcinoma (RCC) risk are mixed. We conducted a meta-analysis to investigate this association.Materials and MethodsEligible studies up to August 31, 2016, were identified and retrieved by searching the MEDLINE and Embase databases along with manual review of the reference lists from the retrieved studies. The quality of the included studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale. The summary relative risk (SRR) and corresponding 95% confidence interval (CI) were calculated using a random-effects model.ResultsTwenty-three publications were included in this meta-analysis: four cohort studies, one pooled study, and 18 case-control studies. The SRR (95% CI) for the highest vs. lowest intake of red meat was 1.36 (1.16–1.58, Pheterogeneity < 0.001); that for processed meat was 1.13 (95% CI, 1.03–1.24, Pheterogeneity = 0.014). Linear dose-response analysis yielded similar results, i.e., the SRR for per 100 g/day increment of red meat and per 50 g/day increment of processed meat was 1.21 (95% CI, 1.08–1.36) and 1.16 (95% CI, 0.99–1.36), respectively. A non-linear association was observed only for red meat (Pnonlinearity = 0.002), and not for processed meat (Pnonlinearity = 0.231). Statistically significant positive associations were observed for intake of beef, salami/ham/bacon/sausage, and hamburger.ConclusionsThis meta-analysis indicates a significant positive association between red and processed meat intake and RCC risk.
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