Objectives:In India control of fertility is based on the folk use of numerous Indian Traditional Plants that has been practiced for contraception from many years. Present investigation aims that, to evaluate the contraceptive potential of Achyranthes aspera leaves MeOH extract in male albino mice and has shown promising results of antispermatogenic, antiandrogenic and hypolipidaemic activities. Materials & Methods:MeOH extract of A. aspera leaves at the doses of 25 mg and 50 mg/100 gm body weight was administered orally for 30 days to adult male albino mice. On day 31st, the rats were sacrificed and the testis were removed and weighed for gravimetrical analysis. Organs were processed for biochemical estimation, histological evaluation and histomorphometry for testicular analysis.Results: Treatment with A. aspera leaves extract resulted in decrease the weight of testis 0.925±0.015 significantly (P<0.05). Morphometric analysis like diameter of testis 2554.22±18.545 seminiferous tubules 247.074±8.051 and Leydig cells 7.842±0.248 were decreased significantly (P<0.05) at 50mg/100gm body weight when compare to control. Spermatogenic elements like, spermatogonia, spermatocytes and spermatids in the testis were reduced significantly (P<0.05) as well as Leydig cells count in testis when compared to control. Biochemical analysis resulted as, protein, glycogen, and cholesterol content were decreased significantly (P<0.05) in testis of extracts treated mice, whereas alkaline phosphatase increased and acid phosphatase decreased when compared with that of control. Conclusion:MeOH extract of A. aspera leaves arrest the spermatogenesis and inhibited testicular function in male mice without side effects to act as potential contraceptive.

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Objective: Karnataka (India) is the darling child of nature where about 722 medicinal plants are available. Ions of different metal elements have an important role in both the reactions. Few elements are essential to the body as nutrients called minerals. Present study deals with trace element analysis were carried out in Indian traditional medicinal spice seeds of Ballari district, Karnataka, India.Methods: 0.25g each of the powdered medicinal plant spice seeds samples digested in 6.5 ml of acid solution to study the trace element like Mn, Fe, Cu, Zn, Cd, and Cr in Coriander seeds, Ajwain seeds, Pepper seeds, Cumin seeds and Sweet cumin seeds at ppm levels were figured out by using AAS analysis.Results: Analysed trace mineral contents of these spice plants resulted highest level of Manganese is 1.92 ppm, Ferrous is 3.69 ppm and in Chromium is 0.0980 ppm in Ajwain seeds, Copper is 0.42 ppm in Coriander seeds, Zinc is 3.02 ppm and Cadmium is 0.0070 ppm in Sweet cumin seeds and lowest were found Mn is 0.65 ppm, Fe is 2.43 ppm in Coriander seeds, Cu is 0.15 ppm in Cumin seeds, Zn is 1.64 ppm in Pepper seeds, Cd is 0.0018 in Ajwain seeds and Cr is 0.0669 ppm in Sweet cumin seeds were studied in (n=3 ppm) all the sample selected spice seeds by AAS and suggests that the monitoring of trace elements in these medicinal plants does not exceed the limiting values set by World Health Organization to use it as a medicinal application. Conclusion:These Indian traditional medicinal spice plant seeds can be safely used for food and medicinal purposes.