INTRODUCTION Diabetes Mellitus (DM) is a disorder of multiple aetiologies, where alteration is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. Diabetes mellitus affects more than 230 million people worldwide and this number is expected to reach 350 million by 2025. Type-2 diabetes mellitus is the most common form of diabetes accounting for 90% of the cases. The chronic hyperglycemia of diabetes is associated with significant long-term squeal, particularly damage and/or dysfunction and failure of various organs, especially the kidneys, eyes, nerves, heart and blood vessels. 1

<strong>Aim</strong>: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. <strong>Materials and Method</strong>: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. <strong>Result</strong>: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol). <strong>Conclusion</strong>: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.

Aim/Background: Serum uric acid is an end product of purine catabolism. The relationship between the serum uric acid adenosine deaminase, lipid profile and oxidative stress in type 2 diabetes mellitus was studied to evaluate its role as one of the risk factor for coronary artery disease. Methods: The serum uric acid level in type 2 diabetes mellitus was compared with controls. The correlation between serum uric acid with adenosine deaminase (ADA), parameters of oxidative stress and serum lipids was also evaluated. Results: We observed serum uric acid level (5.74±0.49) mg/dl is significantly (p<0.001) increased in type 2 diabetes mellitus when compared to controls (4.38±0.41) mg/dl. Increase in serum uric acid level is significantly associated with increase in adenosine deaminase, malondialdehyde (MDA), total antioxidant capacity (TAC), serum triglyceride(TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL Cholesterol). Further we observed a significant negative correlation between HDL cholesterol and the serum uric acid level. Conclusion: We conclude that increase in serum uric acid level in type 2 diabetes mellitus acts as pro-oxidant. The endothelial dysfunction, proliferation of smooth muscle cells, oxidative stress will facilitate atherogenesis and its progression. A strong association between serum total cholesterol, LDL cholesterol, serum triglyceride, and the inverse relationship between the high density lipoprotein cholesterol and serum uric acid observed in the present study suggests that serum uric acid has a role in coronary artery disease.