Background:Chronic autoimmune urticaria (CAU) is one of the most challenging therapeutic problems faced by a dermatologist. Recently, weekly autologous serum injections have been shown to induce a prolonged remission in this disease.Aim:To evaluate the efficacy of repeated autologous serum injections in patients with CAU.Materials and Methods:Seventy patients of CAU were prospectively analyzed for the efficacy of nine consecutive weekly autologous serum injections with a post-intervention follow-up of 12 weeks. Total urticaria severity score (TSS) was monitored at the baseline, at the end of treatment and lastly at the end of 12 weeks of follow up. Response to treatment was judged by the percentage reduction in baseline TSS at the end of treatment and again at the end of 12 weeks-follow-up.Results:Out of the 70 patients enrolled, 11 dropped out of the injection treatment after one or the first few doses only. Among the rest of 59 patients, only 7 patients (12%) went into a partial or complete remission and remained so over the follow-up period of 12 weeks. Forty patients (68%) did not demonstrate any significant reduction in TSS at the end of the treatment period. Rest of the 12 patients showed either a good or excellent response while on weekly injection treatment, but all of them relapsed over the follow-up period of 12 weeks.Conclusion:Autologous serum therapy does not seem to lead to any prolonged remission in patients of CAU.

<p class="abstract"><strong>Background:</strong> Acne scars have a lot of psychosocial implications, they are difficult to treat and can cause depression in the affected patient. The objective of the study was to assess the efficacy of combination of platelet rich plasma (PRP) injections and microneedling in the management of acne scars.</p><p class="abstract"><strong>Methods:</strong> Thirty-five patients with atrophic acne scars were enrolled and graded using Goodman and Baron qualitative grading. Platelet rich plasma injection and microneedling were done at 2-week interval alternatively for a total of 6 sessions of each. Acne scars were graded before and 6 months after starting the treatment. Patients own evaluation of improvement was also recorded.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 12 patients had grade 4 acne scars, 8 (66.6%) improved to grade 2 and 4 (33.3%) improved to grade 3 scars. Out of 15 grade 3 scars, 8(53.3%) improved to grade 1, 7 (46.6%) improved to grade 2. 8 (100%) grade 2 patients improved to grade 1. All patients were highly satisfied with the results.</p><p><strong>Conclusions:</strong> This combination has shown good results in all grades of acne scars.</p>

Lichen scrofulosorum is a tuberculid that is usually seen in children or young adults. Although a rare occurrence, this tuberculid is an important marker of occult tuberculosis, which may not be detected otherwise. We report here a case of lichen scrofulosorum in a ten year-old boy with typical grouped lichenoid papules on the trunk associated with axillary tuberculous lymphadenitis.

Background: Nephrogenic diabetes insipidus (NDI) due to obstructive uropathy is not widely known by physicians and hence not well represented in the literature. To better understand its presentation, clinical course, and available treatments, we conducted a systematic review of case reports on NDI due to urinary tract obstruction. Material and Methods: This observational study was a systematic review of 19 human cases found in the literature. It was done retrospectively to focus on whether NDI can occur due to obstruction of the urinary tract and, if so, what the mechanism (pathophysiology) is. Results: We found that the most common symptom of NDI due to urinary tract obstruction was polyuria. The most common cause of NDI due to urinary tract obstruction was cancer. The most common site for obstruction was the ureter. And the most common test used to confirm the diagnosis was failure to concentrate urine after the administration of desmopressin. Surgical intervention was the most common treatment to relieve obstruction. Conclusion: We found that urinary tract obstruction can cause NDI. With early diagnosis and timely relief of the obstruction, NDI can be reversible.

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