Triple-negative breast cancer (TNBC) is an uncommon subtype of breast cancer that constitutes 15-20% of cases which has a poorer prognosis and lower survival rates (approximately 18 months or less with available treatments) compared to other types of breast cancer. As the name suggests, TNBC is immunohistologically marked by the lack of expression of factors namely estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression and/or amplification of the human epidermal growth factor receptor 2 (HER2)/NEU gene. TNBC is characterized by high grades of Tumor-Infiltrating lymphocytes (TILs), programmed-death ligand 1 (PD-L1) expression, and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) as observed in other cancers too. Hence, metastatic TNBC (mTNBC) therapy focuses on the advancement of immune checkpoint inhibitors which block the above immune checkpoint proteins. The use of Atezolizumab (anti-PD-L1) in combination with nab-paclitaxel (chemotherapy agent) has been marked as a relevant advance in the treatment of metastatic, PD-L1-positive TNBC. It is better to consider advanced and approved diagnostic (VENTANA PD-L1 SP142 assay) in patients who get benefit from treatment with Atezolizumab plus nab-paclitaxel. Keywords: Triple Negative Breast Cancer (TNBC), Atezolizumab, Nab-paclitaxel, Chemotherapy.

Pyogenic liver abscess PLA is an uncommon cause of hospitalisation where majority of cases are polymicrobial and are most frequently caused by seeding of infection from the biliary system. Herein we describe a case of 80-year-old female patient who presented with upper abdominal pain decreased appetite for one week and multiple episodes of vomiting with the content of blood and food particles. The patient complained of other symptoms including fever and significant weight loss. Anaerobic culture of the patient revealed positive growth results with Isolate 1 Bacteroides fragilis and Isolate 2 Peptostreptococcus species. She was treated with IV antibiotics. A positive response to the therapy was observed and the condition of the patient was stable at the time of discharge.