Pyogenic liver abscess PLA is an uncommon cause of hospitalisation where majority of cases are polymicrobial and are most frequently caused by seeding of infection from the biliary system. Herein we describe a case of 80-year-old female patient who presented with upper abdominal pain decreased appetite for one week and multiple episodes of vomiting with the content of blood and food particles. The patient complained of other symptoms including fever and significant weight loss. Anaerobic culture of the patient revealed positive growth results with Isolate 1 Bacteroides fragilis and Isolate 2 Peptostreptococcus species. She was treated with IV antibiotics. A positive response to the therapy was observed and the condition of the patient was stable at the time of discharge.