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These findings reveal high levels of depressive symptomatology among drug users, as well as the possibility of a coexisting depressive syndrome with HCV infection. These findings raise the possibility that depression associated with interferon treatment may, at least partially, be accounted for by preexisting depression. Further research is needed to determine the nature and origins of depression in individuals in treatment with interferon for HCV with specific focus placed on determining the dimensions of depression associated with HCV infection and interferon treatment.

The authors explored the relationships among gender, needle sharing, and depression in a sample of 392 male and 121 female street drug users. Using the Risk Behavior Assessment (National Institute on Drug Abuse, 1991) and the Beck Depression Inventory-2 (A. T. Beck, R. A. Steer, & G. K. Brown, 1996), the authors found that women reported higher levels of depression than men and that sharers endorsed higher levels of depression than nonsharers. Further, the authors found that female sharers reported the highest levels of depression of all groups, that is, as compared with male sharers, female nonsharers, and male nonsharers, who did not differ from one another. This suggests the presence of a special dynamic between gender and depression that is related to higher rates of needle sharing among women.

In a sample of 700 drug users, 64% evidenced comorbidity (i.e., coexisting substance use and psychiatric disorders). Robust relationships between the presence of comorbidity and increased levels of risk behavior, such as needle sharing and trading sex for money, were revealed.

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