Uveal melanoma (UVM) is an adult intraocular malignancy which is the most frequent and has a high tendency for metastasis. This study aims to develop significant differential gene subnetwork between primary and metastatic UVM to identify potential prognostic biomarkers. Differentially expressed genes (DEGs) among three chip datasets were downloaded from Gene Expression Omnibus and identified according to standardization annotation information. Genetic enrichment analyses were utilized to describe biologic functions. The protein‐protein interaction network of DEGs was developed and the module analysis was constructed by STRING and Cytoscape. Kaplan‐Meier method of the integrated expression score was applied to analyze survival outcomes. Functional annotation was assessed to perform GO and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. In addition, ClueGO and gene set enrichment analysis were analyzed to detect underlying significant genes and involved signaling pathways. A total of 103 DEGs with function enrichment were recognized and might be considered as candidate prognostic biomarkers between primary and metastatic UVM. Furthermore, Kaplan‐Meier method suggested that SCD5, SPTBN1, FABP5, SQLE, PTPLA (HACD1), and CDC25B were independent prognostic factors in UVM. Functional annotations indicated that the most involved significant pathways including interferon‐gamma response, IL‐6 JAK STAT3 signaling, TNFA signaling via NFKB and inflammatory response. Significant DEGs between primary and metastatic UVM tissue were identified and might have involved in the metastasis of UVM. SCD5, SPTBN1, FABP5, SQLE, PTPLA (HACD1), and CDC25B transcription levels were of high prognostic value, which might assist us to understand the underlying carcinogenesis or advancement of UVM better.

A new polymeric precursor, poly(phthalazinone ether sulfone) (PPES), was used as precursor to prepare carbon membranes via stabilization and pyrolysis. The thermal stability of PPES was determined by thermogravimetry. The evolution of functional groups of membranes was monitored by ATR-FTIR during the formation process of carbon membranes. The carbon structure of the resultant carbon membranes was analyzed by X-ray diffraction technology. The gas permeation property of carbon membranes was tested by pure gases, H 2 , CO 2 , O 2 , and N 2 . The results show that PPES is a highly thermally stable polymer with the char yield of 38.2 wt % at 700°C in nitrogen. The functional groups of PPES gradually disappeared by forming a graphite-like structure in the membrane matrix during pyrolysis. At the test condition of 0.1 MPa and 30°C, the gas permeabilities of H 2 , CO 2 , O 2 , and N 2 for carbon membranes prepared at the stabilization and pyrolytic temperature of 440 and 650°C are 610.13, 439.90, 146.98, and 26.95 barrer (1 barrer ) 10 -10 cm 3 (STP) cm/(cm 2 s cmHg) ) 3.35 × 10 -16 mol m/(m 2 s Pa)), together with the selectivities of gas pairs H 2 /N 2 , CO 2 /N 2 , and O 2 /N 2 of 22.6, 16.3, and 5.5, respectively.

Photocatalytic water splitting for hydrogen production and water pollutant degradation is a frontier topic to solve energy and environmental problems. In particular, applying electric and magnetic fields on photocatalysts is...

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