A novel soft-hard template approach for preparing photoluminescent carbon dots (CDs) with tunable sizes, compositions, crystalline degrees and photoluminescence properties has been developed using four different precursors as carbon sources. The results offer a new strategy for fabrication of monodispersed CDs with well-defined morphology.

A series of nondimethylphenyl-diarylpyrimidines with much lower cytotoxicities than their dimethyl analogues were developed. Compound B13 with a difluorobiphenyl moiety showed the highest antiviral activity against WT, mutant strains, and RT. The hydrochloride form of B13 exhibited an improved water solubility of 5.6 μg/mL compared with ETR (≪1 μg/mL), better stability in human and rat liver microsomes, and a great oral bioavailability of 44%, making it promising as a drug candidate. In addition, no apparent toxicity was observed in the acute toxicity assay (2 g/kg) and HE staining.

2 Therapeutic.

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