No abstract

The preparation of 4‐ and 5‐acyl‐ and aroyl‐2‐substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4,5‐disubstituted‐2‐aminothiazoles and 7‐(4H)benzothiazolones is discussed. A discussion of the isolation of various intermediates and the mechanistic pathway is also included. A number of 2‐anilino or 2‐benzyl‐4‐ or 5‐aroylthiazoles possessed moderate oral antitubercolosis activity (2).

A series of novel acrylonitrile derivatives containing a flexible chain were designed using cyflumetofen as lead compound. They were synthesized via two steps. The structures were confirmed by 1 H NMR, 13 C NMR and HRMS. The title acrylonitrile derivatives exhibited good acaricidal activity against Tetranchus urticae. In particular, 3j possessed excellent activity in the green house, at the same level as the control Cyflumetofen at 4 days or 7 days.

Dimethylaminomethylen‐thioharnstoffe (I) und Halogenmethylketone (II) kondensieren zu den 2‐Amino‐5‐acyl‐thiazo‐ len (III), aus den entsprechenden Thioamiden (IV) erhält man mit den Phenacylbromiden (V) über die Kondensate (VI) die Cyclisierungsprodukte (VII) bzw. (VIII).