Background: The inflammatory reaction is the main cause of acute respiratory distress syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially those with severe and critical illness. Several studies suggested that high-dose vitamin C reduced inflammatory reaction associated with sepsis and acute respiratory distress syndrome. This study aimed to determine the efficacy and safety of high-dose vitamin C in Coronavirus disease 2019. Methods: We included 76 patients with Coronavirus disease 2019, classified into the high-dose vitamin C group (loading dose of 6g intravenous infusion per 12 hr on the first day, and 6g once for the following 4 days, n=46) and the standard therapy group (standard therapy alone, n=30). Results: The risk of 28-day mortality was reduced for the high-dose vitamin C versus the standard therapy group (HR=0.14, 95% CI, 0.03-0.72). Oxygen support status was improved more with high-dose vitamin C than standard therapy (63.9% vs 36.1%). No safety events were associated with high-dose vitamin C therapy. Conclusion: High-dose vitamin C may reduce the mortality and improve oxygen support status in patients with Coronavirus disease 2019 without adverse events.

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Reverse-dipper BP pattern may serve as an independent risk factor for lacunar infarction and more personalized BP management should be offered to the patients who have elevated nocturnal BP.

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Coronavirus disease 2019 (COVID-19) has now become a worldwide pandemic, and infected countries and districts face extraordinary challenges in constraining the rapid spread of the virus. Nearly a million people have been infected as of April 1, and 42,000 have died worldwide since the December 2019 outbreak in Wuhan, China. The number is still increasing daily at an exponential growth rate. According to the published paper and statistics from the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), severe cases account for nearly 10%, and 5% of patients need mechanical ventilation. Death often occurs in elder people with comorbidities, such as hypertension, coronary heart disease, or diabetes [1].