Biogenesis and tissue development are based on the heterogenesis of multipotent stem cells. However, the underlying mechanisms of stem cell fate specification are unclear. Chirality is one of the most crucial factors that affects stem cell development and is implicated in asymmetrical cell morphology formation; however, its function in heterogeneous cell fate determination remains elusive. In this study, it is reported that the chirality of a constructed 3D extracellular matrix (ECM) differentiates mesenchymal stem cells to diverse lineages of osteogenic and adipogenic cells by providing primary heterogeneity. Molecular analysis shows that left‐handed chirality of the ECM enhances the clustering of the mechanosensor Itgα5, while right‐handed chirality decreases this effect. These differential adhesion patterns further activate distinct mechanotransduction events involving the contractile state, focal adhesion kinase/extracellular signal‐regulated kinase 1/2 cascades, and yes‐associated protein/runt‐related transcription factor 2 nuclear translocation, which direct heterogeneous differentiation. Moreover, theoretical modeling demonstrates that diverse chirality mechanosensing is initiated by biphasic modes of fibronectin tethering. The findings of chirality‐dependent lineage specification of stem cells provide potential strategies for the biogenesis of organisms and regenerative therapies.

The prevalence of various diseases caused by bacteria has been increasing, and some traditional antibiotics have been reported to have varying degrees of resistance. ZnO nanomaterials (ZnO-NMs), due to their excellent broad-spectrum antibacterial properties, lasting antibacterial effects, and excellent biocompatibility, have quickly become the research focus of new antibacterial agents. While the narrow light response range of ZnO-NMs has limited the antibacterial performance to some extent and modifying it by various means to improve its response under visible light, such as doping metal/non-metal atoms, depositing noble metals and coupling carbon materials, which is a new research hotspot. Herein, the current mainstream claims about the antibacterial mechanisms and applications of ZnO-NMs are reviewed.

Surgical excision is the main choice for tongue cancer treatment. However, the physiological functions of oral and maxillofacial regions might be severely impaired and high risk of tongue tumor recurrence cannot be avoided. It is thus becoming urgently important to develop alternative strategies for tongue cancer therapy. In this regard, a new class of near‐infrared (NIR) light‐responsive and peritumoral injectable hydrogel is fabricated with extraordinary photothermal therapy (PTT) for in situ tongue tumors. The as‐prepared soft material exhibits good biocompatibility and ultra‐strong photothermal effect due to the formed network by negatively charged proteins, chitosan molecules, and Ag3AuS2 nanoparticles (NPs). In a well‐constructed in situ tongue tumor model, tumors can be efficiently eradicated by one‐time PTT treatment. Importantly, there are no side effects on surrounding normal tissues and potential tumor recurrence is inhibited. In stark contrast to traditional surgical excision, such biomaterials hold great potential for clinical treatment of oral cancers.

Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive functions can significantly affect the outcomes and daily life in patients. This study examined the gender differences of cognition using the measurement and treatment research to improve cognition in schizophrenia (MATRICS) consensus cognitive battery (MCCB), especially focusing on reasoning and problem solving, and social cognition in schizophrenia patients. The results showed that healthy controls exemplified better cognition than patients in both genders in all examined MCCB scores. Male healthy controls had better reasoning and problem solving and working memory than females, but these gender differences were not presented in schizophrenia patients. Also, male schizophrenia patients showed worse cognition than females on social cognition, processing speed, verbal learning and visual learning. Our results support that male schizophrenia patients had more cognitive impairment than females on reasoning and problem solving, social cognition, processing speed, working memory, verbal learning and visual learning.