Anterior gastric stapling with posterior truncal vagotomy has previously been investigated for its effect on canine gastric acid reduction and motility. Posterior truncal vagotomy could, however, induce reduced pancreatic function, which has been observed after total abdominal vagotomy. In this study, pancreatic secretion has been investigated after anterior gastric stapling with posterior truncal vagotomy in a series of canine experiments by means of a stimulation test. On the long term, no significant postoperative reduction of exocrine pancreatic secretion was observed.