A tolerance study was conducted to determine the palatability of florfenicol to channel catfish Ictalurus punctatus. Four tanks of fish (20 fish/tank) were assigned to each of five treatments distinguished by the amount of florfenicol given in feed per kilogram of body weight, namely, 0, 10, 20, 40, or 100 mg. Fish were fed at a rate of 2.5% of body weight per day for 10 consecutive days. On day 11, all surviving fish were euthanatized, counted, and weighed as a group. Florfenicolmedicated feed was palatable to fish at doses of 10, 20, 40, and 100 mg for 10 consecutive days.

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Abstract. Lead (Pb) poisoning of a pregnant heifer was diagnosed based upon clinical signs (head pressing, blindness, muscle twitching) and a blood lead concentration of 1.73 ppm. Blood and urinary Pb half-lives with CaNa 2 EDTA/thiamine therapy were determined to be 2.08 and 1.38 days, respectively. Many cations (Ca, Fe, Zn, Na, Cu), including Pb, were excreted at higher concentrations in urine during therapy. Blood (0.425 ppm) and liver (4.85 ppm) Pb concentrations in the fetus were 71.7% and 84.3% of the same tissue Pb concentrations of the dam, indicating a significant transfer of Pb in utero. Severe polioencephalomalacia was described in the adult, and hepatic lysosomes with metallic electron densities were present in the fetus.A severely depressed and dehydrated approximately 10-month-old angus heifer (175 kg, estimated) was presented to the Mississippi State University, College of Veterinary Medicine (CVM) Animal Health Center. The herd had recently experienced 2 acute yearling deaths due to unknown causes. This heifer had been found standing in a pond and was reluctant to move. Clinical signs included head pressing, staggering, muscle twitching, and lack of a menace response. Acute toxicosis (lead [Pb], organic pesticides, mercury) or a vitamin deficiency (vitamin A, thiamine) were suspected. Other rule outs included rabies, polioencephalomalacia, thromboembolic meningoencephalitis, listeriosis, and other less common central nervous system (CNS) differential diagnoses. 21 Blood was taken for a complete blood count (CBC) with differential, serum chemistry panel, and blood Pb concentration analysis. Initial therapy (day 0) consisted of thiamine hydrochloride a (1 g, intramuscular [im]), dexamethasone b (20 mg, intravenous [iv]), and oral electrolyte solution c (10 liters via stomach tube).The following morning the neurological signs were more pronounced and included, in addition to those previously noted, hyperesthesia, ptyalism, and bruxism. Blood Pb concentration was 1.73 ppm (CVM Diagnostic Services, Toxicology Laboratory, normal < 0.35 ppm) and the CBC and clinical chemistries were unremarkable. Day 1 treatments were 10 liters electrolyte solution per os, CaNa 2 EDTA d (13 g in 250 ml of saline iv), thiamine hydrochloride (1 g, im), and acepromazine maleate e (18 mg, im

Gross and microscopic effects of arthroscopic partial synovectomy on synovium and articular cartilage of middle carpal joints were studied in 15 horses. A 7-mm diameter motorized synovial resector was inserted into each middle carpal joint and arthroscopic partial synovectomy and lavage or arthroscopic lavage alone was performed. Study periods were 0 (three horses), 16 (three horses), and 30 days (six horses). No gross evidence of degenerative joint disease was observed at day 16 or 30. At 30 days, resected areas lacked villi and there was deposition of fibrin on the synovial surface with varying amounts of newly formed fibrovascular tissue. Thirty days after arthroscopic synovectomy, normal synovium had not formed in equine middle carpal joints.