A series of metal complexes of Zn(II) and Hg(II) having the general composition [M(L)2]X2 [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = Cl−, NO3 − and 1/2SO4 2−] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

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Mononuclear complexes of Cu(II) have been prepared by reacting a 1:1:1 molar ratio of N-phOHA or N-phDHA, dipy or phen and cupric chloride where, N-phOHA = N-phenyl-O-hydroxyacetophenonimine, N-phDHA = N-phenyl-2,4-dihydroxy acetophenonimine, dipy = 2,2′-bipyridil, phen = 1,10-phenanthroline. All complexes were characterized on the basis of their microanalysis data, molar conductance, magnetic moment at room temperature, UV-Vis, IR, 1 H NMR, and ESR spectra. The monomeric and ionic nature of complexes was confirmed by their magnetic moment data and molar conductance values. The ESR spectra of metal chelates in polycrystalline and solution state at 300 K and 77 K were recorded and their silent features are reported. The ESR spectra of the metal chelates provided information about their structure on the basis of Hamiltonian parameters of the complexes and also degree of covalency.

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A series of metal complexes of Ni(II), and Cu(II) having the general composition [M(L) 2 X 2 ] with thiosemicarbazide have been prepared and characterized by elemental chemical analysis, molar conductance, magnetic susceptibility measurements, mass, IR, electron paramagnetic resonance, and electronic spectral studies. The IR spectral data suggest the involvement of sulfur and terminal amino nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for the Ni(II) complexes whereas tetragonal geometry for Cu(II) complexes. Thiosemicarbazide and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.