A 61-year-old man with pulmonary aspergilloma received two antifungals intracavitarily. Although clinical, serological and roentgenographic improvement were observed with fluconazole therapy, bronchial secretions continuously yielded Aspergillusfumigatus. Whenfluconazole was switched to amphotericin B, the pathogen was eradicated immediately. The minimal inhibitory concentrations (MICs) of the isolate were 400 jig/ml for fluconazole, and 0.2 jag/ml for amphotericin B. Although the discrepancy between in vitro and in vivo efficacy of antifungals has been argued, it was suggested the drug of choice should be selected on the basis of the MICresults at least in the intracavitary antifungal therapy for pulmonary aspergilloma. (Internal Medicine 34: 85-88, 1995)
Thin films of (NBCO) were fabricated on MgO (100) substrates by dc magnetron sputtering. The critical parameters for the deposition of the superconducting NBCO thin films were studied. The properties of films strongly depended on the substrate temperature and sputtering gas pressures. The x-ray diffraction pattern showed that the sputter-deposited thin films were highly c-axis oriented. Thin films with could be obtained reproducibly under the optimized sputtering conditions. This film also showed a critical current density of about at 77 K.
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