Introduction : Pelvic inflammatory disease (PID) is an infection of the upper part of the female reproductive system namely the uterus, fallopian tubes, and ovaries, and inside of the pelvis. Objective: to find out the clinical profile of PID in a tertiary care centre. Methods: This was a cross sectional, descriptive study conducted at the Department of Obstetrics and Gynaecology, during period from January to December2016. Total 200 patients complaining of lower abdominal pain, vaginal discharge & having adnexal as well as cervical motion tenderness on bimanual examination between the age group of 18 -45 years were randomly selected for study. Parameters like age, parity, socio-economic status, age of marriage, sexual behavior, Presenting complaints and use of contraceptive were recorded. Results: Most common age group was 20-24 years (29.5%). Maximum number of cases was seen in parity between 2-5 (58%). PID was commonest amongst illiterate women (36%). Maximum number of cases was seen in women from lower socioeconomic class (74%). Out of 200 cases, 79% patients were married, 14 % were remarried. Presenting complaints were pain in abdomen (93.5%), per vaginal discharge (66%), fever (51%). Abdominal tenderness was seen in 95 % of cases. Palpable mass was present in 11 % of cases. Forniceal & cervical motion tenderness were the commonest Per Vaginal examination findings seen in 89% & 84% cases respectively. Conclusion: Incidence of PID was higher in age group between 20-29 years, multipara, women from lower socioeconomic class & illiterate women. Pain in lower abdomen, per vaginal discharge & fever were the commonest complaints. Most of the patients on examination had forniceal & cervical motion tenderness.

The objective of work was to prepare and characterize solid dispersions of valsartan using β-Cyclodextrin to improve its aqueous solubility and rate of dissolution by solvent evaporation technique. Solid dispersions showed marked improvement in the solubility behaviour and improved drug release. From all the formulations VSD4 was found to be optimized formulation based on the characterization, solubility and dissolution studies. The results obtained showed that the aqueous solubility and rate of dissolution was significantly improved when formulated in solid dispersion as compare to pure drug. The enhancement of dissolution rate depends on the nature and amount of the carrier and increases with the increase in the concentration of the carrier. Increase in the dissolution rate may be attributed to; the reduced particle size of drug deposited on the surface of carrier and enhanced wet ability of the drug particles by the carrier. The optimized formulations were evaluated by differential scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM).